2008
Quality control despite mistranslation caused by an ambiguous genetic code
Ruan B, Palioura S, Sabina J, Marvin-Guy L, Kochhar S, LaRossa RA, Söll D. Quality control despite mistranslation caused by an ambiguous genetic code. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 16502-16507. PMID: 18946032, PMCID: PMC2575449, DOI: 10.1073/pnas.0809179105.Peer-Reviewed Original ResearchConceptsGenetic codeAa-tRNAWild-type proteinAminoacyl-tRNA synthetasesInactive mutant proteinsHeat shock responseE. coliMutant proteinsReporter proteinMissense suppressionFunctional proteinsCognate tRNASelective pressureAminoacyl-tRNAActive enzymeShock responseProtein synthesisNative conformationEnergetic costAmino acidsMissense mutationsProteinBiochemical evidenceCorrect pairingProtein quality
1987
Allele-specific complementation of an Escherichia coli leuB mutation by a Lactobacillus bulgaricus tRNA gene
Hottinger H, Ohgi T, Zwahlen M, Dhamija S, Söll D. Allele-specific complementation of an Escherichia coli leuB mutation by a Lactobacillus bulgaricus tRNA gene. Gene 1987, 60: 75-83. PMID: 3326787, DOI: 10.1016/0378-1119(87)90215-0.Peer-Reviewed Original ResearchConceptsTRNA genesCopy numberWild-type formE. coli promotersHigh copy numberGene copy numberLeuB mutationClone bankLeucine prototrophyLow copy numberMissense suppressionNucleotide sequenceSerine tRNATerminator elementsGenesRestoration of activityTRNAEscherichia coliAmino acidsGene allelesExtra armE. coli
1985
Escherichia coli supH suppressor: temperature-sensitive missense suppression caused by an anticodon change in tRNASer2
Thorbjarnardóttir S, Uemura H, Dingermann T, Rafnar T, Thorsteinsdóttir S, Söll D, Eggertsson G. Escherichia coli supH suppressor: temperature-sensitive missense suppression caused by an anticodon change in tRNASer2. Journal Of Bacteriology 1985, 161: 207-211. PMID: 3155715, PMCID: PMC214857, DOI: 10.1128/jb.161.1.207-211.1985.Peer-Reviewed Original ResearchConceptsWild-type tRNASingle nucleotide changeWild-type sequenceCAA anticodonMissense suppressorMissense suppressionCUA anticodonDNA sequencesLeucine codonMutant formsInsertion of serineNucleotide changesSuppressor geneAnticodonTRNASupHTRNASer2Anticodon changeCodonSuppressorSequenceTRNASerCloningGenesSerine
1979
Suppression
Steege D, Söll D. Suppression. Biological Regulation And Development 1979, 433-485. DOI: 10.1007/978-1-4684-3417-0_11.Peer-Reviewed Original ResearchGenetic suppressionType phenotypeFinal gene productsWild-type phenotypePairs of genesInformational suppressorsSuppressor mutationsNonsense suppressionMissense suppressionGene productsMolecular basisFrameshift suppressionGene expressionMutant organismsMolecular mechanismsCell metabolismGenetic selectionGenetic termsMutationsSecondary mutationsTranscriptionMacromolecular componentsPrimary mutationsSuppressorPhenotype