Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction
Li Z, Jiang H, Xie W, Zhang Z, Smrcka A, Wu D. Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction. Science 2000, 287: 1046-1049. PMID: 10669417, DOI: 10.1126/science.287.5455.1046.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesChemokine CCL4Chemotactic FactorsChemotaxis, LeukocyteImmunoglobulin lambda-ChainsIsoenzymesMacrophage Inflammatory ProteinsMiceNeutrophil InfiltrationNeutrophilsN-Formylmethionine Leucyl-PhenylalaninePeritonitisPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhospholipase C betaPhosphorylationSignal TransductionSkin UlcerSuperoxidesType C PhospholipasesProtein Phosphatase 2Cα Dephosphorylates Axin and Activates LEF-1-dependent Transcription*
Wu D, Strovel E, Sussman D. Protein Phosphatase 2Cα Dephosphorylates Axin and Activates LEF-1-dependent Transcription*. Journal Of Biological Chemistry 2000, 275: 2399-2403. PMID: 10644691, DOI: 10.1074/jbc.275.4.2399.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAxin ProteinCOS CellsDishevelled ProteinsDNA-Binding ProteinsEnzyme ActivationJNK Mitogen-Activated Protein KinasesLymphoid Enhancer-Binding Factor 1Mitogen-Activated Protein KinasesPhosphoprotein PhosphatasesPhosphoproteinsPhosphorylationPrecipitin TestsProtein BindingProtein Phosphatase 2Protein Phosphatase 2CProteinsRepressor ProteinsSaccharomyces cerevisiae ProteinsSignal TransductionTranscription FactorsTranscriptional ActivationConceptsLEF-1-dependent transcriptionWnt signal transductionSignal transductionExpression of PP2CProtein phosphatase 2CalphaProtein phosphatase 2CαTwo-hybrid systemDishevelled gene familyReporter gene assayGene familyPositive regulatorCytoplasmic proteinsPP2CNegative regulatorAxinWnt-1Gene assayTranscriptionTransductionRegulatorSynergistic responseProteinExpressionDephosphorylationRepression