2010
Murine visceral leishmaniasis: IgM and polyclonal B‐cell activation lead to disease exacerbation
Deak E, Jayakumar A, Cho KW, Goldsmith‐Pestana K, Dondji B, Lambris JD, McMahon‐Pratt D. Murine visceral leishmaniasis: IgM and polyclonal B‐cell activation lead to disease exacerbation. European Journal Of Immunology 2010, 40: 1355-1368. PMID: 20213734, PMCID: PMC2944234, DOI: 10.1002/eji.200939455.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, ProtozoanAntigen PresentationB-LymphocytesComplement C5aDisease ProgressionFemaleHypergammaglobulinemiaImmunity, InnateImmunization, PassiveImmunoglobulin GImmunoglobulin MInterleukin-10Leishmania infantumLeishmaniasis, VisceralLymph NodesLymphocyte ActivationLymphocyte DepletionMaleMiceMice, Inbred BALB CMice, TransgenicParasitemiaConceptsBALB/c miceC miceDisease exacerbationImmune responseVisceral leishmaniasisB cell-derived IL-10WT BALB/c miceB cell antigen presentationPolyclonal B cell activationAnti-Leishmania responseOngoing immune responseL. infantum infectionHuman visceral leishmaniasisBALB/cB cell expansionIntradermal infection modelB cell activationEstablishment of infectionElevated parasitemiaParasite visceralizationCytokine levelsIL-10Infantum infectionPassive transferAntigen presentation
2006
Immunogenicity of the P-8 amastigote antigen in the experimental model of canine visceral leishmaniasis
Carrillo E, Ahmed S, Goldsmith-Pestana K, Nieto J, Osorio Y, Travi B, Moreno J, McMahon-Pratt D. Immunogenicity of the P-8 amastigote antigen in the experimental model of canine visceral leishmaniasis. Vaccine 2006, 25: 1534-1543. PMID: 17178178, PMCID: PMC2571115, DOI: 10.1016/j.vaccine.2006.10.036.Peer-Reviewed Original ResearchConceptsSoluble Leishmania antigenAmastigote antigensImmune responseAmerican cutaneous leishmaniasis patientsTh1-like immune responseSoluble leishmanial antigenCutaneous leishmaniasis patientsIL-4 mRNAAppropriate immune responseCanine visceral leishmaniasisElicit appropriate immune responsesIdentification of LeishmaniaGeneral vaccinesLeishmanial antigensIL-10Leishmania antigenLeishmaniasis patientsSLA antigensTNF-alphaDisease manifestationsIFN-gammaMurine modelMouse modelVisceral leishmaniasisLeishmania infantum
2004
Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease?
McMahon‐Pratt D, Alexander J. Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease? Immunological Reviews 2004, 201: 206-224. PMID: 15361243, DOI: 10.1111/j.0105-2896.2004.00190.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEvolution, MolecularHost-Parasite InteractionsHumansLeishmaniaLeishmania majorLeishmaniasis, CutaneousLeishmaniasis, VisceralMiceMice, Inbred StrainsVirulenceConceptsMajor histocompatibility complex classDistinct Leishmania speciesLeishmania major infectionResolution of infectionT cell responsesT helper 1Histocompatibility complex classDifferent virulence factorsHost defense mechanismsMajor infectionVisceral diseaseHost macrophage cellsImmune mechanismsVisceral organsParasitic protozoaVaccine developmentCutaneous leishmaniasesSusceptibility/resistanceIntracellular pathogensGenus LeishmaniaControl of diseaseInfectionMacrophage cellsDiseaseLeishmania species
1991
Leishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease.
Barral A, Badaro R, Carvalho E, Barral-Netto M, de Jesus A, Johnson W, Momen H, Almeida R, McMahon-Pratt D, Pedral-Sampaio D, Grimaldi G. Leishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease. American Journal Of Tropical Medicine And Hygiene 1991, 44: 536-46. PMID: 2063957, DOI: 10.4269/ajtmh.1991.44.536.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrazilHumansLeishmaniaLeishmania braziliensisLeishmaniasisLeishmaniasis, MucocutaneousLeishmaniasis, VisceralConceptsMucocutaneous leishmaniasisCutaneous leishmaniasisClinical presentationVisceral leishmaniasisCases of CLMonoclonal antibodiesLeishmania amazonensisCases of DCLL. amazonensis infectionDifferent clinical presentationsDifferent clinical formsDifferent Leishmania speciesAmazonensis infectionClinical groundsIndistinguishable clinical presentationDermal leishmaniasisSpecific monoclonal antibodiesClinical formsClinical diseaseLeishmanial diseaseL. chagasiWide spectrumLeishmania referenceLeishmaniasisL. amazonensis
1990
Prophylactic Immunization against Experimental Leishmania donovani Infection by Use of a Purified Protein Vaccine
White A, McMahon-Pratt D. Prophylactic Immunization against Experimental Leishmania donovani Infection by Use of a Purified Protein Vaccine. The Journal Of Infectious Diseases 1990, 161: 1313-1314. PMID: 2345310, DOI: 10.1093/infdis/161.6.1313.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, ProtozoanAntigens, ProtozoanFemaleLeishmania donovaniLeishmaniasis, VisceralMiceMice, Inbred BALB CProtozoan ProteinsVaccination
1987
Serodiagnostic assay for visceral leishmaniasis employing monoclonal antibodies
Jaffe C, McMahon-Pratt D. Serodiagnostic assay for visceral leishmaniasis employing monoclonal antibodies. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 1987, 81: 587-594. PMID: 3445339, DOI: 10.1016/0035-9203(87)90418-4.Peer-Reviewed Original ResearchConceptsVisceral leishmaniasisMonoclonal antibodiesSerodiagnostic assaysVL seraParasite antigensChagas diseaseSystemic lupus erythematosusNon-endemic areasDifferent parasite antigensLeishmania antigenLupus erythematosusMucocutaneous leishmaniasisLepromatous leprosyNegative control seraPositive casesSpecies-specific monoclonal antibodiesNormal serumControl seraRapid diagnosisAntigenSerum dilutionSerumAntibodiesLeishmaniasisSpecific inhibition
1984
Production and characterization of species-specific monoclonal antibodies against Leishmania donovani for immunodiagnosis.
Jaffe C, Bennett E, Grimaldi G, McMahon-Pratt D. Production and characterization of species-specific monoclonal antibodies against Leishmania donovani for immunodiagnosis. The Journal Of Immunology 1984, 133: 440-7. PMID: 6373932, DOI: 10.4049/jimmunol.133.1.440.Peer-Reviewed Original ResearchConceptsMonoclonal antibodiesVisceral leishmaniasisSpecies-specific monoclonal antibodiesL. donovaniAntibody DAntigenic determinantsLeishmania donovaniKala-azar serumWestern blot analysisSpecies of LeishmaniaSerologic assaysEpidemiologic studiesClinical diagnosisWestern blotAntigenic moleculesProtein antigensRadioimmunoprecipitation analysisAntibodiesLeishmaniasisLeishmania speciesLeishmania stocksDonovaniMonoclonal antibody DBlot analysisAntigen