2010
Megasomes in Leishmania
McMahon-Pratt D, Ueda-Nakamura T, Traub-Csekö Y. Megasomes in Leishmania. Microbiology Monographs 2010, 17: 131-148. DOI: 10.1007/978-3-642-12863-9_6.Peer-Reviewed Original ResearchImportance of lysosomesProtein traffickingLeishmania virulenceResident enzymesMammalian hostsLysosome-like structuresLeishmania mexicana complexParasite existLysosomal hydrolasesTargeting mechanismCysteine proteinasesSerious public health problemPublic health problemMexicana complexPhlebotomine sandfliesLesion amastigotesGenus LeishmaniaAmastigote formsGood targetClassic pathwayPathwayPromastigote formsHealth problemsMegasomesInsects
2000
Internalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis
Kima P, Constant S, Hannum L, Colmenares M, Lee K, Haberman A, Shlomchik M, McMahon-Pratt D. Internalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis. Journal Of Experimental Medicine 2000, 191: 1063-1068. PMID: 10727468, PMCID: PMC2193117, DOI: 10.1084/jem.191.6.1063.Peer-Reviewed Original ResearchConceptsFc receptorsB cell antigen presentationMurine cutaneous leishmaniasisFunctional B cellsCommon gamma chainL. mexicana complexLeishmania infectionAntigen presentationCutaneous leishmaniasisB cellsLeishmania pathogenesisInfectionComplex parasitesCritical roleAntibodiesMexicana complexPathogenesisMiceGamma chainReceptorsParasitesLeishmaniasis
1993
Identification of two distinct cysteine proteinase genes of Leishmania pifanoi axenic amastigotes using the polymerase chain reaction
Traub-Cseko Y, Duboise M, Boukai L, McMahon-Pratt D. Identification of two distinct cysteine proteinase genes of Leishmania pifanoi axenic amastigotes using the polymerase chain reaction. Molecular And Biochemical Parasitology 1993, 57: 101-115. PMID: 8426606, DOI: 10.1016/0166-6851(93)90248-v.Peer-Reviewed Original ResearchConceptsC-terminal extensionCysteine proteinase geneComparative sequence analysisCysteine proteinasesActive site residuesAmastigote cysteine proteinasesMexicana complexChromosome locationGenomic arrangementDistinct genesCDNA sequenceSequence dataDNA sequencesTrypanosoma bruceiProtein sequencesBiological functionsProteinase geneSite residuesDegenerate primersSelective conservationLysosomal organellesGlycine residueGenomic copiesSequence analysisLeishmania mexicana complex
1992
Loss of the GP46/M-2 surface membrane glycoprotein gene family in the Leishmania braziliensis complex
McMahon-Pratt D, Traub-Cseko Y, Lohman K, Rogers D, Beverley S. Loss of the GP46/M-2 surface membrane glycoprotein gene family in the Leishmania braziliensis complex. Molecular And Biochemical Parasitology 1992, 50: 151-160. PMID: 1542309, DOI: 10.1016/0166-6851(92)90252-f.Peer-Reviewed Original ResearchConceptsGP46/MGene familyGlycoprotein gene familyMolecular karyotype analysisBraziliensis complexLeishmania braziliensis complexSpeciation eventsTrypanosomatid speciesPhylogenetic analysisCrithidia fasciculataLeishmania tarentolaeDevelopmental cycleWestern blot analysisLeishmania mexicana complexMembrane glycoproteinsKaryotype analysisBlot analysisL. braziliensis complexProtein expressionPolyclonal antiserumMexicana complexSpeciesL. panamensisLeishmania majorL. braziliensis
1987
Identification and distribution of New World Leishmania species characterized by serodeme analysis using monoclonal antibodies.
Grimaldi G, David J, McMahon-Pratt D. Identification and distribution of New World Leishmania species characterized by serodeme analysis using monoclonal antibodies. American Journal Of Tropical Medicine And Hygiene 1987, 36: 270-87. PMID: 3826486, DOI: 10.4269/ajtmh.1987.36.270.Peer-Reviewed Original ResearchConceptsWide geographic distributionWide geographical distributionWild reservoir hostsSubspecies levelNew World LeishmaniaMolecular markersGeographic distributionL. mexicana complexL. braziliensis complexSpecific monoclonal antibodiesGeographical distributionL. donovani chagasiL. mexicanaMexicana complexReservoir hostsMonoclonal antibodiesParasite identificationBraziliensis complexL. donovani complexMexicanaStocks of LeishmaniaL. braziliensisIsolatesComplexesLeishmania