2011
Increased Tubular Proliferation as an Adaptive Response to Glomerular Albuminuria
Guo JK, Marlier A, Shi H, Shan A, Ardito TA, Du ZP, Kashgarian M, Krause DS, Biemesderfer D, Cantley LG. Increased Tubular Proliferation as an Adaptive Response to Glomerular Albuminuria. Journal Of The American Society Of Nephrology 2011, 23: 429-437. PMID: 22193389, PMCID: PMC3294312, DOI: 10.1681/asn.2011040396.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminuriaAnimalsAxl Receptor Tyrosine KinaseCell ProliferationDisease Models, AnimalFemaleHeparin-binding EGF-like Growth FactorIntegrasesIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsKidney GlomerulusKidney Tubules, ProximalMaleMembrane ProteinsMiceMice, TransgenicPodocytesProteinuriaProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesConceptsGlomerular proteinuriaTubular injuryTubular proliferationStructural glomerular injuryProteinuric renal diseaseOnset of albuminuriaRenal tubular atrophyDiphtheria toxin receptorRenal tubular cellsProximal tubule cellsGlomerular albuminuriaRenal failureSystemic inflammationTubular damageProgressive glomerulosclerosisRenal diseaseTubular atrophyGlomerular injuryRenal responsePodocyte lossProliferative responseTubular cellsAnimal modelsProteinuriaReceptor Axl
2005
Bone marrow plasticity revisited: protection or differentiation in the kidney tubule?
Krause D, Cantley LG. Bone marrow plasticity revisited: protection or differentiation in the kidney tubule? Journal Of Clinical Investigation 2005, 115: 1705-1708. PMID: 16007248, PMCID: PMC1159151, DOI: 10.1172/jci25540.Peer-Reviewed Original ResearchConceptsBone marrow-derived cellsMarrow-derived cellsTubule repairBone marrowEpithelial cellsStem cellsIschemic injuryRenal interstitiumTubular cellsRenal epithelial cellsCell lossTubular segmentsRenal cellsKidney tubulesMajority of dataEndogenous cellsHigh rateRecent reportsKidneyMarrowRepairCellsTubulesProliferationStem cell niche