2015
Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation
Zhang PX, Cheng J, Zou S, D'Souza AD, Koff JL, Lu J, Lee PJ, Krause DS, Egan ME, Bruscia EM. Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation. Nature Communications 2015, 6: 6221. PMID: 25665524, PMCID: PMC4324503, DOI: 10.1038/ncomms7221.Peer-Reviewed Original ResearchConceptsCF macrophagesMiR-199aMicroRNA-199aHyper-inflammatory responseCFTR-deficient miceCystic fibrosis patientsCystic fibrosis lungLung destructionDisease morbidityPharmacological modulationCF miceCF lungFibrosis patientsInnate immunityLungMacrophagesCAV1 expressionDrug celecoxibReduced levelsTLR4CelecoxibMiceCav1PathwayMorbidity
2007
Circulating stem cells in extremely preterm neonates
Bizzarro MJ, Bhandari V, Krause DS, Smith BR, Gross I. Circulating stem cells in extremely preterm neonates. Acta Paediatrica 2007, 96: 521-525. PMID: 17391470, DOI: 10.1111/j.1651-2227.2007.00194.x.Peer-Reviewed Original ResearchConceptsWeeks of lifePreterm neonatesNeonatal morbidityPulmonary functionPremature neonatesGestational agePeripheral bloodInitial CD34Median gestational agePulmonary function testsShort-term outcomesUmbilical cord bloodFunction testsNeonatal demographicsBirth weightCord bloodRespiratory diseaseNeonatesCell countCD34Progenitor cellsInverse correlationWeeksBloodMorbidity