2019
Proinsulin Expressing Neuroendocrine Tumors of the Pancreas
Celli R, Tang LH, Cai G, Freedman-Weiss M, Colunga M, Salem RR, Majumdar S, Jain D. Proinsulin Expressing Neuroendocrine Tumors of the Pancreas. Pancreas 2019, 48: 55-59. PMID: 30451800, DOI: 10.1097/mpa.0000000000001196.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdultAgedBiomarkers, TumorBlood GlucoseFemaleHumansHypoglycemiaInsulinInsulinomaMaleMiddle AgedNeuroendocrine TumorsPancreatic NeoplasmsProinsulinConceptsPancreatic neuroendocrine tumorsNeuroendocrine tumorsAvailable clinicopathologic dataIHC-negative tumorsSurgical oncology centersNormal insulin levelsIHC-positive tumorsSerum proinsulinClinicopathologic featuresPNET patientsClinicopathologic dataHypoglycemic patientsInsulin levelsProspective studyOncology centersSerum glucoseSuch tumorsClinical significanceInsulin immunohistochemistryRare casePatientsImmunohistochemistryProinsulinomaTumorsInsulinoma
2017
A Systematic Review of Proinsulin-Secreting Pancreatic Neuroendocrine Tumors
Murtha TD, Lupsa BC, Majumdar S, Jain D, Salem RR. A Systematic Review of Proinsulin-Secreting Pancreatic Neuroendocrine Tumors. Journal Of Gastrointestinal Surgery 2017, 21: 1335-1341. PMID: 28510792, DOI: 10.1007/s11605-017-3428-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAgedBiomarkers, TumorFemaleHumansInsulinomaMiddle AgedNeuroendocrine TumorsPancreatic NeoplasmsProinsulinConceptsPancreatic neuroendocrine tumorsNeuroendocrine tumorsSystematic reviewRare pancreatic neuroendocrine tumorYale-New Haven HospitalMajority of patientsMedian tumor diameterLower insulin levelsBiomedical databases PubMedNew Haven HospitalSymptomatic hypoglycemiaMost patientsFemale predominanceTumor diameterClinicopathologic featuresInsulin levelsUncommon diseaseMean ageOvid MEDLINEHormonal levelsDatabases PubMedPatientsProinsulinomaHormone productionTumors
2015
Focal hepatic glycogenosis associated with metastatic insulinoma presenting as mass lesions
Vyas M, Zhang X, Morrow JS, Jain D, Salem RR, West AB. Focal hepatic glycogenosis associated with metastatic insulinoma presenting as mass lesions. Pathology - Research And Practice 2015, 212: 59-62. PMID: 26627264, DOI: 10.1016/j.prp.2015.11.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleGlycogenGlycogen Storage DiseaseHepatocytesHumansInsulinomaLiverLiver NeoplasmsMaleNeoplasm MetastasisPancreatic Neoplasms
2012
PDX-1, CDX-2, TTF-1, and CK7
Chan ES, Alexander J, Swanson PE, Jain D, Yeh MM. PDX-1, CDX-2, TTF-1, and CK7. The American Journal Of Surgical Pathology 2012, 36: 737-743. PMID: 22498824, DOI: 10.1097/pas.0b013e31824aba59.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCDX2 Transcription FactorDiagnosis, DifferentialDNA-Binding ProteinsFemaleHomeodomain ProteinsHumansImmunohistochemistryIntestinal NeoplasmsKeratin-20Keratin-7Liver NeoplasmsLung NeoplasmsMaleMiddle AgedNeuroendocrine TumorsPancreatic NeoplasmsSensitivity and SpecificitySingle-Blind MethodTrans-ActivatorsTranscription FactorsConceptsGI neuroendocrine tumorsThyroid transcription factor-1Pancreatic neuroendocrine tumorsBronchopulmonary neuroendocrine tumorsMetastatic neuroendocrine tumorsPrimary neuroendocrine tumorNeuroendocrine tumorsCDX-2PDX-1Primary siteMetastatic pancreatic neuroendocrine tumorsPrimary pancreatic neuroendocrine tumorsDuodenal neuroendocrine tumorsΒ-cell functionSimilar morphologic featuresPancreatic duodenal homeobox-1Good overall diagnostic accuracyOverall diagnostic accuracyDuodenal homeobox 1Radiologic dataTranscription factor 1IHC panelImmunohistochemical markersIHC analysisKeratin 7
2011
Genetic Effects and Modifiers of Radiotherapy and Chemotherapy on Survival in Pancreatic Cancer
Zeng H, Yu H, Lu L, Jain D, Kidd MS, Saif MW, Chanock SJ, Hartge P, Risch H. Genetic Effects and Modifiers of Radiotherapy and Chemotherapy on Survival in Pancreatic Cancer. Pancreas 2011, 40: 657-663. PMID: 21487324, PMCID: PMC3116071, DOI: 10.1097/mpa.0b013e31821268d1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overATP Binding Cassette Transporter, Subfamily G, Member 2ATP-Binding Cassette TransportersCase-Control StudiesConnecticutDihydrouracil Dehydrogenase (NADP)FemaleGenetic MarkersGenetic VariationGenome-Wide Association StudyHumansMaleMiddle AgedNeoplasm ProteinsPancreatic NeoplasmsPolymorphism, Single NucleotidePrognosisProportional Hazards ModelsSerpinsSurvival AnalysisTreatment OutcomeConceptsPancreatic cancerOverall survivalCancer survivalProportional hazards regression modelsSurvival of patientsPopulation-based studyPancreatic cancer survivalHazards regression modelsGerm-line genetic variationEvidence of associationClinical outcomesCancer patientsTreatment outcomesTreatment responseSignificant associationPatientsCancerPrevious genome-wide association study dataRadiotherapyPutative markerGenetic polymorphismsSurvivalDPYD geneChemotherapyEvidence of interactionPseudointraductal papillary mucinous neoplasia caused by microscopic periductal endocrine tumors of the pancreas: a report of 3 cases
Kenney B, Singh G, Salem RR, Paterno F, Robert ME, Jain D. Pseudointraductal papillary mucinous neoplasia caused by microscopic periductal endocrine tumors of the pancreas: a report of 3 cases. Human Pathology 2011, 42: 1034-1041. PMID: 21292301, DOI: 10.1016/j.humpath.2010.09.018.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, MucinousAgedCarcinoma, PapillaryDiagnosis, DifferentialFemaleHumansMiddle AgedPancreatic DuctsPancreatic NeoplasmsConceptsIntraductal papillary mucinous neoplasmPapillary mucinous neoplasmMucinous neoplasmsEndocrine tumorsPancreatic ductEndocrine neoplasmsDistinctive pancreatic tumorsExtensive mucin productionMain pancreatic ductPancreatic endocrine tumorsConstellation of findingsPancreatic endocrine neoplasmsDuct stricturesMucinous neoplasiaCystic lesionsPancreatic tumorsMucin productionNeoplasmsPapillary epitheliumTumorsDuctSuch casesConvincing featuresResectionStricture
2008
p120 Catenin Reduction and Cytoplasmic Relocalization Leads to Dysregulation of E-Cadherin in Solid Pseudopapillary Tumors of the Pancreas
Chetty R, Jain D, Serra S. p120 Catenin Reduction and Cytoplasmic Relocalization Leads to Dysregulation of E-Cadherin in Solid Pseudopapillary Tumors of the Pancreas. American Journal Of Clinical Pathology 2008, 130: 71-76. PMID: 18550473, DOI: 10.1309/feyd99txc4lmyva5.Peer-Reviewed Original Research
2005
Diagnostic intraoperative imprint cytology of a solid pseudopapillary tumor of the pancreas
Mariappan MR, Fadare O, Jain D, Chacho MS. Diagnostic intraoperative imprint cytology of a solid pseudopapillary tumor of the pancreas. Diagnostic Cytopathology 2005, 32: 351-352. PMID: 15880718, DOI: 10.1002/dc.20194.Peer-Reviewed Original Research
2004
Inhibin Expression in Ovarian-type Stroma in Mucinous Cystic Neoplasms of the Pancreas
Yeh MM, Tang LH, Wang, Robert ME, Zheng W, Jain D. Inhibin Expression in Ovarian-type Stroma in Mucinous Cystic Neoplasms of the Pancreas. Applied Immunohistochemistry & Molecular Morphology 2004, 12: 148-152. PMID: 15354741, DOI: 10.1097/00129039-200406000-00009.Peer-Reviewed Original ResearchConceptsOvarian-type stromaMucinous cystic neoplasmCases of MCNProgesterone receptorSolid pseudopapillary neoplasmTheca-like cellsEstrogen receptorCystic neoplasmsPseudopapillary neoplasmStandard indirect immunoperoxidase methodPancreatic mucinous cystic neoplasmIntraductal papillary mucinous tumorMucinous cystic tumorsOvarian stromal tissueComplex hormonal interactionsNormal pancreatic tissueIndirect immunoperoxidase methodInhibin expressionPR positivityMucinous tumorsFemale patientsCystic tumorOvarian stromaSerous cystadenomaAlpha-inhibin