1987
Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor
Stern DF, Hare DL, Cecchini MA, Weinberg RA. Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor. Science 1987, 235: 321-324. PMID: 3492043, DOI: 10.1126/science.3492043.Peer-Reviewed Original Research
1986
Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor.
Stern DF, Roberts AB, Roche NS, Sporn MB, Weinberg RA. Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor. Molecular And Cellular Biology 1986, 6: 870-877. PMID: 3022135, PMCID: PMC367587, DOI: 10.1128/mcb.6.3.870.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Polyomavirus TransformingAntigens, Viral, TumorCell DivisionCell Transformation, NeoplasticCells, CulturedEpidermal Growth FactorGenesGenes, ViralGrowth SubstancesOncogene Proteins, ViralOncogenesPeptidesPlatelet-Derived Growth FactorPolyomavirusRatsRats, Inbred F344TransfectionTransforming Growth FactorsConceptsEpidermal growth factorPlatelet-derived growth factorExogenous growth factorsSoft agarRas oncogeneGrowth factorEGF-like factorsPresence of PDGFControl cellsAnchorage-independent growthMyc-transfected cellsRas-transfected cellsPresence of EGFLike genesMYCResponsiveness of cellsGrowth factor productionOncogeneAutocrine stimulationNumerous coloniesTGF betaLack of responsivenessGenesSelective stimulationStimulatory effectDevelopment of monoclonal antibodies reactive with the product of the neu oncogene.
Drebin JA, Link VC, Stern DF, Weinberg RA, Greene MI. Development of monoclonal antibodies reactive with the product of the neu oncogene. Symposium On Fundamental Cancer Research 1986, 38: 277-89. PMID: 3749645.Peer-Reviewed Original ResearchMolecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles.
Hung MC, Schechter AL, Chevray PY, Stern DF, Weinberg RA. Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 261-264. PMID: 3001730, PMCID: PMC322837, DOI: 10.1073/pnas.83.2.261.Peer-Reviewed Original ResearchConceptsOncogenic alleleIdentical restriction enzyme patternsOncogene-encoded proteinsDihydrofolate reductase geneNIH 3T3 cellsProtein-encoding regionsCell surface proteinsMethotrexate-resistant coloniesGross structural alterationsRestriction enzyme patternsNeu geneGene clonesMolecular cloningGrowth factor receptorDNA sequencesErbB geneReductase geneGenesSurface proteinsNeu oncogeneFactor receptorMolecular cloneEnzyme patternsProteinP185 protein
1985
Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies
Drebin J, Link V, Stern D, Weinberg R, Greene M. Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies. Cell 1985, 41: 695-706. PMID: 2860972, DOI: 10.1016/s0092-8674(85)80050-7.Peer-Reviewed Original ResearchConceptsNIH 3T3 cellsAnchorage-independent growthAnti-p185 monoclonal antibodiesColony formationSoft agar colony formationAgar colony formationOncogene protein productGene productsNontransformed phenotypeProtein productsAntibody treatmentRas oncogeneDNA transfectionMonoclonal antibodiesNeu gene productSoft agarOncogenePhenotypeCellsP185P185 levelsNeuroblastoma linesUnrelated specificityControl antibodyNeu oncogeneType beta transforming growth factor: a bifunctional regulator of cellular growth.
Roberts AB, Anzano MA, Wakefield LM, Roche NS, Stern DF, Sporn MB. Type beta transforming growth factor: a bifunctional regulator of cellular growth. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 119-123. PMID: 3871521, PMCID: PMC396983, DOI: 10.1073/pnas.82.1.119.Peer-Reviewed Original ResearchConceptsGrowth factorEpidermal growth factorColony formationAnchorage-independent growthNRK fibroblastsType betaPlatelet-derived growth factorHuman lung carcinoma cellsLung carcinoma cellsBreast carcinoma cell linesCarcinoma cell linesCellular myc geneLung carcinomaHuman tumor cellsHuman melanomaAnchorage-dependent growthHuman placentaTumor cellsCarcinoma cellsCell cycle timeHuman plateletsCell linesSoft agarTwo-chain polypeptideBifunctional regulator
1984
Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene
Drebin J, Stern D, Link V, Weinberg R, Greene M. Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene. Nature 1984, 312: 545-548. PMID: 6504162, DOI: 10.1038/312545a0.Peer-Reviewed Original ResearchConceptsNIH 3T3 cellsCell surface antigensCellular oncogenesAnimal cancer cellsNormal NIH 3T3 cellsMonoclonal antibodiesTumor-associated antigensVariety of antigensRelative molecular massCell surface determinantsNon-malignant cellsGenetic elementsDifferent histological originDNA transfectantsDNA transfectionMolecular massNeoplastic processAntibody reactivityNeoplastic cellsMalignant cellsHistological originAntigenIdentical antigensOncogeneCancer cellsThe neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen
Schechter A, Stern D, Vaidyanathan L, Decker S, Drebin J, Greene M, Weinberg R. The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature 1984, 312: 513-516. PMID: 6095109, DOI: 10.1038/312513a0.Peer-Reviewed Original Research