Featured Publications
Catalysis‐Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass
Zimmerman K, Liu X, von Kroge S, Stabach P, Lester ER, Chu EY, Srivastava S, Somerman MJ, Tommasini SM, Busse B, Schinke T, Carpenter TO, Oheim R, Braddock DT. Catalysis‐Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass. Journal Of Bone And Mineral Research 2020, 37: 1733-1749. PMID: 35773783, PMCID: PMC9709593, DOI: 10.1002/jbmr.4640.Peer-Reviewed Original ResearchConceptsHeterotopic mineralizationBone massFibroblast growth factor 23Growth factor 23Low bone massSoft tissue calcificationEarly-onset osteoporosisFrizzled-related protein 1Soluble Wnt inhibitorsTrabecular bone microarchitectureENPP1 deficiencyΒ-catenin signalingFactor 23Plasma FGF23Vascular calcificationArterial calcificationNuclear β-cateninPlasma PPiBone microarchitectureMurine modelTissue calcificationPlasma PiWnt inhibitorsCalcificationMice
2020
Phylogeny and chemistry of biological mineral transport
Schlesinger PH, Braddock DT, Larrouture QC, Ray EC, Riazanski V, Nelson DJ, Tourkova IL, Blair HC. Phylogeny and chemistry of biological mineral transport. Bone 2020, 141: 115621. PMID: 32858255, PMCID: PMC7771281, DOI: 10.1016/j.bone.2020.115621.Peer-Reviewed Original ResearchConceptsImportant evolutionary relationshipsTissue-nonspecific alkaline phosphataseJawless fishEvolutionary relationshipsMineral accumulationKey biological elementsCellular organizationNonspecific alkaline phosphataseCross-linked collagen fibrilsMembrane vesiclesMineral transportSkeletal elementsAmorphous aggregatesDefinitive stageBone physiologyHigh expressionTooth formationMetabolic featuresEpithelial transport