Noise in gene expression is coupled to growth rate
Keren L, van Dijk D, Weingarten-Gabbay S, Davidi D, Jona G, Weinberger A, Milo R, Segal E. Noise in gene expression is coupled to growth rate. Genome Research 2015, 25: 1893-1902. PMID: 26355006, PMCID: PMC4665010, DOI: 10.1101/gr.191635.115.Peer-Reviewed Original ResearchConceptsGene expression noiseExpression noiseGene expressionGlobal changeLower growth rateDifferent growth ratesDifferent cell cycle stagesAverage gene expressionNutrient-poor conditionsEnvironmental conditionsCell cycle stageOverall high variabilityGrowth rateMost promotersCell cycle heterogeneityCellular regulationPromoter featuresDisplay elevated levelsExpression variabilityBiological functionsExpression distributionPhenotypic implicationsAsynchronous populationIdentical cellsExpression valuesSlow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage
van Dijk D, Dhar R, Missarova AM, Espinar L, Blevins WR, Lehner B, Carey LB. Slow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage. Nature Communications 2015, 6: 7972. PMID: 26268986, PMCID: PMC4557116, DOI: 10.1038/ncomms8972.Peer-Reviewed Original ResearchConceptsTranscriptional stress responseDNA damageDNA damage responseIsogenic populationsRNA polymerase fidelityDamage responseTranscriptional differencesIsogenic cellsEnvironmental stressCell variabilityStress responseGrowth ratePolymerase fidelityCulture conditionsPolymerase error rateOxidative stressCellsSuch cellsSame environmentTranscriptomeTransposonSubpopulationsTranscriptsGenotypicStress