Featured Publications
Ovarian Aging and Fertility
Seifer D, Feinberg E, Hsu A. Ovarian Aging and Fertility. JAMA 2024, 332 PMID: 39470648, DOI: 10.1001/jama.2024.18207.Peer-Reviewed Original ResearchOvarian agingInfertility
2024
Moving toward Narrowing the United States Gap in Assisted Reproductive Technology (ART) Racial and Ethnic Disparities in the Next Decade
Mahabamunuge J, Seifer D. Moving toward Narrowing the United States Gap in Assisted Reproductive Technology (ART) Racial and Ethnic Disparities in the Next Decade. Journal Of Clinical Medicine 2024, 13: 2224. PMID: 38673497, PMCID: PMC11050514, DOI: 10.3390/jcm13082224.Peer-Reviewed Original Research
2022
ICSI IS ASSOCIATED WITH LOWER BLASTULATION RATES COMPARED TO CONVENTIONAL IVF AMONG COUPLES WITH NON-MALE FACTOR INFERTILITY AND LOW OOCYTE YIELD
Beroukhim G, Seifer D, Chaplia O, Nichols-Burns S, Basar M, Halicigil C. ICSI IS ASSOCIATED WITH LOWER BLASTULATION RATES COMPARED TO CONVENTIONAL IVF AMONG COUPLES WITH NON-MALE FACTOR INFERTILITY AND LOW OOCYTE YIELD. Fertility And Sterility 2022, 118: e143. DOI: 10.1016/j.fertnstert.2022.08.419.Peer-Reviewed Original Research
2021
The Impact of Intracytoplasmic Sperm Injection in Non-Male Factor Infertility—A Critical Review
Glenn TL, Kotlyar AM, Seifer DB. The Impact of Intracytoplasmic Sperm Injection in Non-Male Factor Infertility—A Critical Review. Journal Of Clinical Medicine 2021, 10: 2616. PMID: 34198564, PMCID: PMC8231975, DOI: 10.3390/jcm10122616.Peer-Reviewed Original ResearchNon-male factor infertilityUse of ICSIIntracytoplasmic sperm injectionTotal fertilization failureFactor infertilityMale factor infertilityFertilization failureSperm injectionSafety of offspringLive birth rateFertilization rateICSI useSurveillance studyInfertilityBirth rateHigh rateInjectionNumerous studiesFailurePatientsIVFCorrection to: Psychological experience and coping strategies of patients in the Northeast US delaying care for infertility during the COVID-19 pandemic
Seifer DB, Petok WD, Agrawal A, Glenn TL, Bayer AH, Witt BR, Burgin BD, Lieman HJ. Correction to: Psychological experience and coping strategies of patients in the Northeast US delaying care for infertility during the COVID-19 pandemic. Reproductive Biology And Endocrinology 2021, 19: 66. PMID: 33910567, PMCID: PMC8079515, DOI: 10.1186/s12958-021-00746-9.Peer-Reviewed Original Research
2020
OVERCOMPENSATING? THE USE OF ICSI FOR NON-MALE FACTOR INFERTILITY DOES NOT IMPROVE LIVE BIRTH RATE IN A MATCHED PATIENT POPULATION
Glenn T, Kelk D, Wininger M, Seifer D. OVERCOMPENSATING? THE USE OF ICSI FOR NON-MALE FACTOR INFERTILITY DOES NOT IMPROVE LIVE BIRTH RATE IN A MATCHED PATIENT POPULATION. Fertility And Sterility 2020, 114: e299-e300. DOI: 10.1016/j.fertnstert.2020.08.820.Peer-Reviewed Original Research
2017
Vitamin D deficiency is associated with poor reproductive outcomes in PCOS but not unexplained infertility
Butts S, Seifer D, Senapati S, Koelper N, Legro R, Diamond M. Vitamin D deficiency is associated with poor reproductive outcomes in PCOS but not unexplained infertility. Fertility And Sterility 2017, 108: e69-e70. DOI: 10.1016/j.fertnstert.2017.07.220.Peer-Reviewed Original ResearchDifferences in utilization of Intracytoplasmic sperm injection (ICSI) within human services (HHS) regions and metropolitan megaregions in the U.S.
Zagadailov P, Hsu A, Seifer DB, Stern JE. Differences in utilization of Intracytoplasmic sperm injection (ICSI) within human services (HHS) regions and metropolitan megaregions in the U.S. Reproductive Biology And Endocrinology 2017, 15: 45. PMID: 28606175, PMCID: PMC5469007, DOI: 10.1186/s12958-017-0263-4.Peer-Reviewed Original ResearchConceptsLive birth rateIntracytoplasmic sperm injectionHuman Services (HHS) regionsBirth rateUse of ICSIHigher live birth rateNon-donor cyclesUS practice patternsMale factor infertilityHigh rateDepartment of HealthFactor infertilityMale factorPractice patternsInfertility rateClinic groupSperm injectionHuman service groupsDisease controlWomenClinicInfertilityLower ratesService regionArt differs
2011
Cultural factors contributing to health care disparities among patients with infertility in Midwestern United States
Missmer SA, Seifer DB, Jain T. Cultural factors contributing to health care disparities among patients with infertility in Midwestern United States. Fertility And Sterility 2011, 95: 1943-1949. PMID: 21420677, DOI: 10.1016/j.fertnstert.2011.02.039.Peer-Reviewed Original ResearchConceptsInfertility careHospital-based fertility centerUniversity hospital-based fertility centerHealth care accessHealth care disparitiesAfrican American womenHealth care systemPercent of respondentsConsecutive womenMedian ageFertility centerPatient raceMAIN OUTCOMECare accessHispanic womenCare disparitiesSelf-administered surveyTreatment opinionsInfertilityWhite womenCare systemStigma of infertilityWomenDemographic characteristicsCare
2008
Follicular-fluid neurotrophin levels in women undergoing assisted reproductive technology for different etiologies of infertility
Buyuk E, Seifer DB. Follicular-fluid neurotrophin levels in women undergoing assisted reproductive technology for different etiologies of infertility. Fertility And Sterility 2008, 90: 1611-1615. PMID: 18222435, DOI: 10.1016/j.fertnstert.2007.08.085.Peer-Reviewed Original ResearchConceptsMale factor infertilityDifferent etiologiesOvarian reserveNerve growth factorBDNF levelsNeurotrophin levelsBrain-derived neurotrophic factor levelsNT-3 concentrationNeurotrophic factor levelsProspective observational studyDiminished ovarian reserveHistory of endometriosisPolycystic ovarian syndromeIVF cyclesOvarian syndromeNGF levelsFollicular fluidNeurotrophin concentrationsObservational studyMAIN OUTCOMENGF concentrationsInfertilityFactor levelsEndometriosisEtiology
2007
Follicular fluid brain derived neurotrophic factor (BDNF) levels in women undergoing ART for different etiologies of infertility
Buyuk E, Seifer D. Follicular fluid brain derived neurotrophic factor (BDNF) levels in women undergoing ART for different etiologies of infertility. Fertility And Sterility 2007, 88: s167. DOI: 10.1016/j.fertnstert.2007.07.580.Peer-Reviewed Original ResearchSocial concerns of women undergoing infertility treatment
Finamore PS, Seifer DB, Ananth CV, Leiblum SR. Social concerns of women undergoing infertility treatment. Fertility And Sterility 2007, 88: 817-821. PMID: 17418158, DOI: 10.1016/j.fertnstert.2007.01.009.Peer-Reviewed Original ResearchConceptsInfertility treatment centersFrequent doctor visitsCaribbean-American womenCross-sectional questionnaireRace/ethnicityInfertility specialistsInfertility statusInfertility treatmentDoctor visitsMAIN OUTCOMENumber of visitsHigh school educationMost womenTreatment centersDemographic dataInfertilityWomenDemographic characteristicsSuccess rateAmerican womenCertain womenVisitsLevel of educationQuestionnaireAssociation
2002
Detection and Therapeutic Approaches to Age-Related Infertility
Sharara F, Scott R, Seifer D. Detection and Therapeutic Approaches to Age-Related Infertility. 2002, 24-38. DOI: 10.1007/978-3-642-87690-5_3.Peer-Reviewed Original Research
2001
Contribution of diminished ovarian reserve to hypofertility associated with endometriosis.
Hock DL, Sharafi K, Dagostino L, Kemmann E, Seifer DB. Contribution of diminished ovarian reserve to hypofertility associated with endometriosis. The Journal Of Reproductive Medicine 2001, 46: 7-10. PMID: 11209637.Peer-Reviewed Original ResearchConceptsStage III/IV endometriosisStage I/II endometriosisOvarian reserveFSH levelsFertilization/embryo transferHigh E2 levelsStage of endometriosisDay 3 levelsMale factor infertilityCase-control studyAge-matched controlsFactor infertilityE2 levelsEndometriosisEmbryo transferTotal groupProgressive lossControl levelsWomenSignificant differencesE2FSHLevelsPatientsInfertility
2000
Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values?
Trout S, Seifer D. Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values? Fertility And Sterility 2000, 74: 335-337. PMID: 10927054, DOI: 10.1016/s0015-0282(00)00625-7.Peer-Reviewed Original ResearchConceptsDay 3 serum FSHRecurrent pregnancy lossUnexplained recurrent pregnancy lossCauses of RPLSerum FSHPregnancy lossControl groupOvarian reserveDay 3 FSHUnexplained habitual abortionDiminished ovarian reservePresence of infertilityHistory of infertilityRetrospective comparative analysisUnexplained groupRPL groupHabitual abortionMean ageMAIN OUTCOMEFSHGreater incidenceTest groupWomenPotential roleInfertility
1998
The detection of diminished ovarian reserve in infertile women
Sharara F, Scott R, Seifer D. The detection of diminished ovarian reserve in infertile women. American Journal Of Obstetrics And Gynecology 1998, 179: 804-812. PMID: 9757994, DOI: 10.1016/s0002-9378(98)70087-0.Peer-Reviewed Original ResearchConceptsOvarian reserveOwn gametesDiminished ovarian reserveFetal cardiac activityLower chanceReproductive technologiesInfertility populationInfertile womenProvocative testsPregnancy lossPregnancy rateInvasive therapyHigh incidenceExpensive treatmentWomenCardiac activityLate 30sEarly 40sMultiple testingDaily challengesPregnancyUltrasonographyInfertilityTherapyCliniciansTesting the Ovarian Reserve in Infertile Women
Sharara F, Seifer D. Testing the Ovarian Reserve in Infertile Women. The Endocrinologist 1998, 8: 279-283. DOI: 10.1097/00019616-199807000-00008.Peer-Reviewed Original ResearchOvarian reserveInfertile womenDiminished ovarian reserveFetal cardiac activityGroup of womenInfertility populationPerimenopausal periodDonor oocytesPregnancy lossInvasive therapyHigh incidenceOwn gametesEarly signsPotential predictorsWomenLower chanceCardiac activityReproductive technologiesLongitudinal studyMultiple testingDaily challengesMenopauseInfertilityTherapyClinicians
1997
The impact of hydrosalpinx on successful pregnancy in tubal factor infertility treated by in vitro fertilization
Blazar A, Hogan J, Seifer D, Frishman G, Wheeler C, Haning R. The impact of hydrosalpinx on successful pregnancy in tubal factor infertility treated by in vitro fertilization. Fertility And Sterility 1997, 67: 517-520. PMID: 9091340, DOI: 10.1016/s0015-0282(97)80079-9.Peer-Reviewed Original ResearchConceptsTubal factor infertilityTubal diseaseFactor infertilityPregnancy rateCycle cancellation rateSuccess of IVFNumber of oocytesNumber of embryosHydrosalpinx groupRoutine salpingectomyOvarian stimulationOngoing pregnancyImplantation rateSuccessful pregnancyHydrosalpinxMAIN OUTCOMECancellation ratePatientsOocyte fertilizationInfertilityIVFIVF facilityPregnancyMore cyclesFertilization rate