2020
Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin
Martin EC, Vicari C, Tsakou-Ngouafo L, Pontarotti P, Petrescu AJ, Schatz DG. Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin. Mobile DNA 2020, 11: 17. PMID: 32399063, PMCID: PMC7204232, DOI: 10.1186/s13100-020-00214-y.Peer-Reviewed Original ResearchProtostome genomesAdjacent gene pairsProtostome lineageBilaterian evolutionBilaterian ancestorJawed vertebratesProtostome evolutionBilateria cladeEarly deuterostomesEvolutionary historyBilaterian originGene pairsPhylogenetic analysisMultiple duplicationsRAG2 geneProtostomesEvolutionary precursorTransposase activityEarly bilateriansRibbon wormsIntact elementsGenomeDeuterostomesTransposonJ recombination
1996
Neoteny in Lymphocytes: Rag1 and Rag2 Expression in Germinal Center B Cells
Han S, Zheng B, Schatz D, Spanopoulou E, Kelsoe G. Neoteny in Lymphocytes: Rag1 and Rag2 Expression in Germinal Center B Cells. Science 1996, 274: 2094-2097. PMID: 8953043, DOI: 10.1126/science.274.5295.2094.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesDNA NucleotidyltransferasesDNA-Binding ProteinsFemaleGene ExpressionGene RearrangementGenes, ImmunoglobulinGenes, RAG-1Germinal CenterHomeodomain ProteinsImmunizationImmunoglobulin Class SwitchingLymphocyte ActivationMiceMice, Inbred C57BLPolymerase Chain ReactionProtein BiosynthesisProteinsVDJ RecombinasesConceptsGerminal center B cellsAntigen receptor genesT cell antigen receptor genesRAG2 proteinsB cellsRAG2 geneRAG genesRAG2 expressionFunctional immunoglobulinPeyer's patch germinal centersMessenger RNAGenesRAG1Receptor geneActivated B cellsNormal adult animalsLymphocyte populationsImmature lymphocytesGerminal centersBone marrowMurine splenicAntibody repertoireCellsAdult animalsExpression