2000
Role for GDNF in Biochemical and Behavioral Adaptations to Drugs of Abuse
Messer C, Eisch A, Carlezon W, Whisler K, Shen L, Wolf D, Westphal H, Collins F, Russell D, Nestler E. Role for GDNF in Biochemical and Behavioral Adaptations to Drugs of Abuse. Neuron 2000, 26: 247-257. PMID: 10798408, PMCID: PMC4451194, DOI: 10.1016/s0896-6273(00)81154-x.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDrugs of abuseAnti-GDNF antibodyIntra-VTA infusionDopaminergic brain regionsSubsequent drug exposureChronic morphineDrug exposureTegmental areaChronic cocaineCocaine exposureRewarding effectsGDNF geneGDNF pathwayBrain regionsGDNFBehavioral sensitivityCocaineDrugsMorphineInfusionPresent studyExposureNull mutationAbuse
1996
Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens.
Widnell K, Self D, Lane S, Russell D, Vaidya V, Miserendino M, Rubin C, Duman R, Nestler E. Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens. Journal Of Pharmacology And Experimental Therapeutics 1996, 276: 306-15. PMID: 8558448.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCyclic AMP Response Element-Binding ProteinCyclic AMP-Dependent Protein KinasesDown-RegulationGTP-Binding ProteinsMaleMolecular Sequence DataMorphineNucleus AccumbensOligonucleotides, AntisenseProtein Sorting SignalsRatsRats, Sprague-DawleyRNA, MessengerSensitivity and SpecificitySignal TransductionConceptsCAMP response element-binding proteinEffects of morphineNucleus accumbensBrain regionsCREB levelsChronic opiate administrationCAMP pathwayTranscription factor cAMP response element-binding proteinResponse element-binding proteinProperties of opiatesMorphine administrationAnti-sense oligonucleotide strategyMorphine actionOpiate administrationSustained decreaseLong-term effectsElement-binding proteinNervous systemCREB expressionOpiate addictionCREB immunoreactivityDetectable toxicityVivo evidenceMorphineAccumbens