Gene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device
Hickerson RP, Wey WC, Rimm DL, Speaker T, Suh S, Flores MA, Gonzalez-Gonzalez E, Leake D, Contag CH, Kaspar RL. Gene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device. Molecular Therapy - Nucleic Acids 2013, 2: e129. PMID: 24150576, PMCID: PMC4027428, DOI: 10.1038/mtna.2013.56.Peer-Reviewed Original ResearchMolecular Therapy-Nucleic Acids (2013) 2Mouse skin modelStratum corneum barrierSkin disordersHypodermic needleSuccessful clinical translationMurine skinMicroneedle array technologyPainful methodPainClinical translationSiRNASkinStratum corneumPotent moleculesInefficient deliveryDelivery devicesInjectionSkin modelReporter gene expressionGene expressionSiRNA deliveryDeliveryPatientsClinic