Locus coeruleus lesions and resistance to extinction of a classically conditioned response: Involvement of the neocortex and hippocampus
McCormick D, Thompson R. Locus coeruleus lesions and resistance to extinction of a classically conditioned response: Involvement of the neocortex and hippocampus. Brain Research 1982, 245: 239-249. PMID: 7127072, DOI: 10.1016/0006-8993(82)90806-x.Peer-Reviewed Original ResearchConceptsDepletion of norepinephrineExtinction deficitNon-lesioned controlsBilateral electrolytic lesionsLocus coeruleus lesionsHippocampal norepinephrineLocus coeruleusNE depletionDopamine levelsHippocampal samplesElectrolytic lesionsDay 3Control groupNorepinephrineBrain regionsHypothalamus/Significant differencesThird groupUnpaired trainingLesionsNM responseUnpaired extinctionConditioned responseSignificant depletionAnimals