Increased macrophage uptake of irreversibly glycated albumin modified-low density lipoproteins of normal and diabetic subjects is mediated by non-saturable mechanisms
Dobrian A, Lazar V, Tirziu D, Simionescu M. Increased macrophage uptake of irreversibly glycated albumin modified-low density lipoproteins of normal and diabetic subjects is mediated by non-saturable mechanisms. Biochimica Et Biophysica Acta 1996, 1317: 5-14. PMID: 8876621, DOI: 10.1016/0925-4439(96)00017-8.Peer-Reviewed Original ResearchConceptsAGE-AlbAdvanced glycosylation end productsDiabetic subjectsDensity lipoproteinAGE-albuminModified-low density lipoproteinsMacrophage uptakeOxidative-antioxidative balanceIndependent risk factorNon-saturable pathwayLow-density lipoproteinNon-saturable mechanismReceptor-mediated uptakeGlycosylation end productsLevel of glycationDiabetes mellitusDiabetic stateRisk factorsAtherosclerotic plaquesLipid peroxidesAcetylated LDLPeritoneal macrophagesReceptor pathwayLipoproteinDLDL