Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation
Post MJ, Sato K, Murakami M, Bao J, Tirziu D, Pearlman JD, Simons M. Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation. AJP Regulatory Integrative And Comparative Physiology 2005, 290: r494-r500. PMID: 16254127, DOI: 10.1152/ajpregu.00460.2005.Peer-Reviewed Original ResearchConceptsChronic myocardial ischemiaCollateral formationMyocardial ischemiaBlood flowPig modelAdvanced coronary artery diseaseGrowth factorCoronary artery diseaseHypoxia-inducible factor-1alphaRegional blood flowUpregulation of VEGFDose-dependent mannerFGF receptor expressionArtery diseaseCollateral scoreIschemic myocardiumIndividual growth factorsMyocardial functionReceptor expressionReal-time PCRRegional perfusionLocal VEGFPeptide injectionAngiogenic therapyRegional function