Syndecan-4 Clustering Induces Cell Migration in a PDZ-Dependent Manner
Tkachenko E, Elfenbein A, Tirziu D, Simons M. Syndecan-4 Clustering Induces Cell Migration in a PDZ-Dependent Manner. Circulation Research 2006, 98: 1398-1404. PMID: 16675718, DOI: 10.1161/01.res.0000225283.71490.5a.Peer-Reviewed Original ResearchConceptsCell migrationPDZ-dependent mannerAdhesion pointsActivation of Rac1Induces cell migrationPDZ domainEndothelial cell migrationFocal adhesionsCytoplasmic domainSignal transductionCell motilityDomain interactionsEndothelial cellsSyndecan-4Cell polarizationPDZRac1Fide receptorLigand clusteringLive cellsDirection of migrationElevated basal levelsSynectinS4 mutantLeading edge