Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation
Post MJ, Sato K, Murakami M, Bao J, Tirziu D, Pearlman JD, Simons M. Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation. AJP Regulatory Integrative And Comparative Physiology 2005, 290: r494-r500. PMID: 16254127, DOI: 10.1152/ajpregu.00460.2005.Peer-Reviewed Original ResearchConceptsChronic myocardial ischemiaCollateral formationMyocardial ischemiaBlood flowPig modelAdvanced coronary artery diseaseGrowth factorCoronary artery diseaseHypoxia-inducible factor-1alphaRegional blood flowUpregulation of VEGFDose-dependent mannerFGF receptor expressionArtery diseaseCollateral scoreIschemic myocardiumIndividual growth factorsMyocardial functionReceptor expressionReal-time PCRRegional perfusionLocal VEGFPeptide injectionAngiogenic therapyRegional functionDelayed Arteriogenesis in Hypercholesterolemic Mice
Tirziu D, Moodie KL, Zhuang ZW, Singer K, Helisch A, Dunn JF, Li W, Singh J, Simons M. Delayed Arteriogenesis in Hypercholesterolemic Mice. Circulation 2005, 112: 2501-2509. PMID: 16230502, DOI: 10.1161/circulationaha.105.542829.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoprotein B-48Apolipoproteins BBlood Flow VelocityDisease Models, AnimalEndothelium, VascularFemoral ArteryHumansIn Vitro TechniquesIschemiaMagnetic Resonance ImagingMiceMice, KnockoutNeovascularization, PhysiologicOligonucleotide Array Sequence AnalysisReceptors, LDLUmbilical VeinsConceptsFemoral artery ligationControl miceLaser Doppler imagingArtery ligationTissue perfusionDay 7Doppler imagingReceptor 1Strain-matched control miceVascular cell adhesion molecule-1Monocyte/macrophage influxCell adhesion molecule-1Hypercholesterolemic low-density lipoproteinDistal limb perfusionMacrophage scavenger receptor 1Growth factor therapyIschemia-induced angiogenesisRestoration of perfusionAdhesion molecule-1Arterial blood flowHypoxia-inducible factor-1alphaLow-density lipoproteinScavenger receptor 1Controls 3 daysFactor therapy