A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA–tetraglycinate
Coman D, Kiefer GE, Rothman DL, Sherry AD, Hyder F. A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA–tetraglycinate. NMR In Biomedicine 2011, 24: 1216-1225. PMID: 22020775, PMCID: PMC3267016, DOI: 10.1002/nbm.1677.Peer-Reviewed Original ResearchConceptsResponsive contrast agentsChemical exchange saturation transferMolecular imagingNonexchangeable proton resonancesMolecular imaging agentsLanthanide complexesCEST characteristicsIon complexesBiosensing propertiesBulk waterProton exchangeProton resonancesTetraacetate derivativeNonexchangeable protonsQuantitative molecular imagingRedundant deviationExchangeable sitesInner sphereSaturation transferImaging agentCEST methodComplexesIonsContrast agentsGreat potential