2021
Imaging extracellular acidification and immune activation in cancer
Hyder F, Coman D. Imaging extracellular acidification and immune activation in cancer. Current Opinion In Biomedical Engineering 2021, 18: 100278. PMID: 33997581, PMCID: PMC8115219, DOI: 10.1016/j.cobme.2021.100278.Peer-Reviewed Original ResearchGene-centric viewMetabolic reprogrammingHostile ecosystemCancer hallmarksHabitat acidificationHost cellsFuture cancer therapyAerobic glycolysisDiverse mechanismsMetabolic interactionsExtracellular acidificationDifferent nutrientsCancer cellsImmune cellsDisease tissuesCellsTumor milieuNutrientsCancer therapyMetabolismRecent evidenceIncidental phenomenonAcidificationReprogrammingOncogene
2020
Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy
Liu W, Deacon J, Yan H, Sun B, Liu Y, Hegan D, Li Q, Coman D, Parent M, Hyder F, Roberts K, Nath R, Tillement O, Engelman D, Glazer P. Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy. Translational Oncology 2020, 13: 100839. PMID: 32763504, PMCID: PMC7408331, DOI: 10.1016/j.tranon.2020.100839.Peer-Reviewed Original ResearchHuman lung cancer cellsA549 human lung cancer cellsMolecular MRI techniqueTumor-bearing miceLung cancer cellsClonogenic survival assaysVivo radiosensitizationRadiation therapySolid tumorsTumor cell metabolismTumorsEnhanced radiosensitivityTumor cellsMR imagingSurvival assaysMRI techniquesCancer cellsTreatment planningRadiotherapyTumor coreGeneral hallmarkRadiotherapy treatment planningRadiosensitivityPeptide deliveryDelivery