2022
Incorporating the image formation process into deep learning improves network performance
Li Y, Su Y, Guo M, Han X, Liu J, Vishwasrao H, Li X, Christensen R, Sengupta T, Moyle M, Rey-Suarez I, Chen J, Upadhyaya A, Usdin T, Colón-Ramos D, Liu H, Wu Y, Shroff H. Incorporating the image formation process into deep learning improves network performance. Nature Methods 2022, 19: 1427-1437. PMID: 36316563, PMCID: PMC9636023, DOI: 10.1038/s41592-022-01652-7.Peer-Reviewed Original Research
2011
A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development
Christensen R, de la Torre-Ubieta L, Bonni A, Colón-Ramos DA. A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development. Development 2011, 138: 5257-5267. PMID: 22069193, PMCID: PMC3210501, DOI: 10.1242/dev.069062.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsForkhead Transcription FactorsImmunohistochemistryMicroscopy, FluorescenceNeuritesNeurogenesisPhosphatidylinositol 3-KinaseProtein IsoformsRNA InterferenceRNA, Small InterferingSignal TransductionTranscription FactorsTransgenesConceptsDAF-16/FOXOPI3KDAF-18/PTENC. elegans developmentSignal transduction cascadeNeurite outgrowthMajor negative regulatorPI3K pathway activityDaf-18Caenorhabditis elegansDAF-16Transduction cascadeFOXO pathwayNegative regulatorNeuronal cell morphologyNovel roleFOXOMammalian neuronsCorrect developmentPathway activityF isoformsNovel mechanismCell morphologyPathwayNeuronal morphology