2021
Infant Nasopharyngeal Microbiota Subphenotypes and Early Childhood Lung Function: Evidence from a Rural Ghanaian Pregnancy Cohort
Dubowski K, Kaali S, Jack D, Prah RKD, Clemente JC, Tawiah T, Mujtaba M, Iddrisu L, Carrión D, Konadu DG, Agyei O, Kornu FM, Osei-Owusu S, Lee AG, Asante KP. Infant Nasopharyngeal Microbiota Subphenotypes and Early Childhood Lung Function: Evidence from a Rural Ghanaian Pregnancy Cohort. International Journal Of Environmental Research And Public Health 2021, 18: 7276. PMID: 34299726, PMCID: PMC8305530, DOI: 10.3390/ijerph18147276.Peer-Reviewed Original ResearchConceptsLung functionNasopharyngeal microbiotaPregnancy cohortLung healthPolymerase chain reactionRespiratory microbiotaLatent class analysisMassTag polymerase chain reactionGhana Randomized Air PollutionFuture lung healthChildhood lung functionSmall airway resistanceMultivariable linear regression modelsProspective pregnancy cohortAge four yearsAsymptomatic childrenMiddle-income countriesPulmonary diseaseAirway resistanceImpulse oscillometryNasopharyngeal swabsSubphenotypesCohortMore pathogensChain reactionPrenatal household air pollutant exposure is associated with reduced size and gestational age at birth among a cohort of Ghanaian infants
Quinn AK, Adjei IA, Ae-Ngibise KA, Agyei O, Boamah-Kaali EA, Burkart K, Carrión D, Chillrud SN, Gould CF, Gyaase S, Jack DW, Kaali S, Kinney PL, Lee AG, Mujtaba MN, Oppong FB, Owusu-Agyei S, Yawson A, Wylie BJ, Asante KP. Prenatal household air pollutant exposure is associated with reduced size and gestational age at birth among a cohort of Ghanaian infants. Environment International 2021, 155: 106659. PMID: 34134048, PMCID: PMC8628363, DOI: 10.1016/j.envint.2021.106659.Peer-Reviewed Original ResearchConceptsLow birth weightHousehold air pollutionGestational ageBirth weightPlacental malariaMaternal exposureBirth lengthSubstantial public health benefitsGhana Randomized Air PollutionReduced birth weightImportant risk factorMalaria-endemic areasAge z-scoreEvidence of malariaPublic health benefitsAir pollutant exposureEffects of COMalarial statusPlacental histopathologyBirth outcomesPregnant womenFetal growthPrenatal exposureRisk factorsGhanaian infants
2019
Examining the relationship between household air pollution and infant microbial nasal carriage in a Ghanaian cohort
Carrión D, Kaali S, Kinney PL, Owusu-Agyei S, Chillrud S, Yawson AK, Quinn A, Wylie B, Ae-Ngibise K, Lee AG, Tokarz R, Iddrisu L, Jack DW, Asante KP. Examining the relationship between household air pollution and infant microbial nasal carriage in a Ghanaian cohort. Environment International 2019, 133: 105150. PMID: 31518936, PMCID: PMC6868532, DOI: 10.1016/j.envint.2019.105150.Peer-Reviewed Original ResearchConceptsNasal carriageExposure-response relationshipHealthy controlsPneumonia casesMassTag polymerase chain reactionGhana Randomized Air PollutionHousehold air pollution exposureExposure-response analysisAir pollution exposureViral carriageHousehold air pollutionTreat comparisonArm participantsITT analysisStudy armsNasopharyngeal swabsGhanaian cohortPolymerase chain reactionLeading causeMicrobial carriageMoraxella catarrhalisRespiratory microbesChildhood mortalityHealth StudyPneumonia