2013
Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels
Jastreboff AM, Sinha R, Lacadie C, Small DM, Sherwin RS, Potenza MN. Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels. Diabetes Care 2013, 36: 394-402. PMID: 23069840, PMCID: PMC3554293, DOI: 10.2337/dc12-1112.Peer-Reviewed Original ResearchConceptsFood cuesFood cravingsStress cuesBrain responsesSubjective food cravingsFavorite-food cuesBrain regionsInsulin levelsNeural correlatesBrain activationHOMA-IRObese individualsInsulin sensitivityFood motivationNeural activityFunctional MRICuesCravingHOMA-IR levelsNeurocircuitryLean subjectsInsulin resistanceLean individualsObesity associationHypothalamic regions
2008
Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele
Stice E, Spoor S, Bohon C, Small DM. Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele. Science 2008, 322: 449-452. PMID: 18927395, PMCID: PMC2681095, DOI: 10.1126/science.1161550.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesBasal GangliaBody Mass IndexCaudate NucleusCorpus StriatumCuesDeoxyribonucleases, Type II Site-SpecificDopamineEatingFemaleFoodHumansHyperphagiaMagnetic Resonance ImagingObesityPolymorphism, Restriction Fragment LengthPutamenReceptors, Dopamine D2Regression AnalysisRewardSignal TransductionWeight GainConceptsDorsal striatumTaqIA restriction fragment length polymorphismConsummatory food rewardMagnetic resonance imaging studyStriatal dopamine receptorsDevelopment of obesityA1 alleleResonance imaging studyFunctional magnetic resonance imaging studyDopamine D2 receptor geneTaqIA A1 alleleObese individualsStriatal dopamineD2 receptor geneProspective dataLean individualsDopamine receptorsFood intakeStriatumImaging studiesStriatal responsesStriatal activationGenetic polymorphismsReceptor geneObesity