2016
Perceptual and Brain Response to Odors Is Associated with Body Mass Index and Postprandial Total Ghrelin Reactivity to a Meal
Sun X, Veldhuizen MG, Babbs AE, Sinha R, Small DM. Perceptual and Brain Response to Odors Is Associated with Body Mass Index and Postprandial Total Ghrelin Reactivity to a Meal. Chemical Senses 2016, 41: 233-248. PMID: 26826114, PMCID: PMC4850930, DOI: 10.1093/chemse/bjv081.Peer-Reviewed Original ResearchConceptsBody mass indexMass indexHealthy weight subjectsBrain responsesFunctional magnetic resonance imagingMagnetic resonance imagingGhrelin suppressionWeight subjectsMetabolic healthFree fatty acidsMetabolic measuresAnimal studiesBody weightResonance imagingOlfactory-guided behaviorDifferential brain responsesEndocrine influencesChemosensory stimuliMetabolic peptidesMetabolic responseOlfactory sensitivityHuman researchInconsistent resultsMealFatty acids
2012
Midbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger
Nolan-Poupart S, Veldhuizen MG, Geha P, Small DM. Midbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger. Appetite 2012, 60: 168-174. PMID: 23064394, PMCID: PMC3526000, DOI: 10.1016/j.appet.2012.09.032.Peer-Reviewed Original ResearchConceptsAbsence of hungerFunctional magnetic resonance imagingSubsequent intakeRatings of hungerPeriaqueductal gray regionMidbrain responsesMagnetic resonance imagingKey reward regionsPalatable milkshakeSignificant positive associationPalatable foodResonance imagingInsular responsesOrbitofrontal cortexNeural circuitsGreater intakeMilkshake consumptionIntakeReward regionsBrain responsesEnhanced responseMilkshakePositive associationMidbrainGray regionNeuroimaging the interaction of mind and metabolism in humans
D’Agostino A, Small DM. Neuroimaging the interaction of mind and metabolism in humans. Molecular Metabolism 2012, 1: 10-20. PMID: 24024114, PMCID: PMC3757655, DOI: 10.1016/j.molmet.2012.06.002.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingParticular mental processesNeural circuitsInteraction of mindFood cuesMental processesBrain responsesNeural responsesPsychological stateFunctional neuroimagingNeuroimaging techniquesDecision-making processMagnetic resonance imagingHormonal factorsCuesResonance imagingNeuroimagingMetabolic signalsMindHormonal signalsDesireSatietyBehaviorIntakeResponseAcute stress potentiates brain response to milkshake as a function of body weight and chronic stress
Rudenga KJ, Sinha R, Small DM. Acute stress potentiates brain response to milkshake as a function of body weight and chronic stress. International Journal Of Obesity 2012, 37: 309-316. PMID: 22430303, PMCID: PMC3381866, DOI: 10.1038/ijo.2012.39.Peer-Reviewed Original ResearchConceptsBody mass indexFunctional magnetic resonance imagingChronic stressOrbitofrontal cortexRight amygdalaBody weightPalatable foodAcute stressBasal cortisol levelsBrain responsesAmygdala responseMagnetic resonance imagingStress-related eatingMilkshake receiptPalatable milkshakeObese womenOverweight womenMass indexRight amygdala responseOFC responsesPotentiates responsesCortisol levelsLeft amygdalaResonance imagingVentral striatum
2008
Relation of Reward From Food Intake and Anticipated Food Intake to Obesity: A Functional Magnetic Resonance Imaging Study
Stice E, Spoor S, Bohon C, Veldhuizen MG, Small DM. Relation of Reward From Food Intake and Anticipated Food Intake to Obesity: A Functional Magnetic Resonance Imaging Study. Journal Of Psychopathology And Clinical Science 2008, 117: 924-935. PMID: 19025237, PMCID: PMC2681092, DOI: 10.1037/a0013600.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingAdolescent girlsGreater activationFunctional magnetic resonance imaging studySomatosensory regionsRelation of rewardGustatory cortexDopamine receptor availabilityMagnetic resonance imaging studyResonance imaging studyChocolate milkshakeTasteless solutionConsequent weight gainFood intakeBrain regionsGreater rewardsHedonic aspectsDecreased activationWeak activationRewardReceptor availabilityMilkshakeGirlsImaging studiesMagnetic resonance imagingSleep deprivation alters functioning within the neural network underlying the covert orienting of attention
Mander BA, Reid KJ, Davuluri VK, Small DM, Parrish TB, Mesulam MM, Zee PC, Gitelman DR. Sleep deprivation alters functioning within the neural network underlying the covert orienting of attention. Brain Research 2008, 1217: 148-156. PMID: 18511023, PMCID: PMC2528837, DOI: 10.1016/j.brainres.2008.04.030.Peer-Reviewed Original ResearchConceptsReaction time benefitsFunctional magnetic resonance imagingSpatial attentionPosterior cingulate cortex activationTime benefitsLeft intraparietal sulcusGoal-directed interactionsSleep-deprived individualsSleep deprivation altersInvalid cuesUninformative cuesNeural resourcesValid cuesCovert orientingSelective attentionIrrelevant locationsPCC activationIntraparietal sulcusUpcoming eventsCortex activationBrain activityNormal restPCC activityCuesYoung adults
2005
Perceptual differences between chemical stimuli presented through the ortho‐ or retronasal route
Hummel T, Heilmann S, Landis B, Reden J, Frasnelli J, Small D, Gerber J. Perceptual differences between chemical stimuli presented through the ortho‐ or retronasal route. Flavour And Fragrance Journal 2005, 21: 42-47. DOI: 10.1002/ffj.1700.Peer-Reviewed Original ResearchRetronasal presentationChemosensory stimuliOlfactory event-related potentialsFunctional magnetic resonance imagingMagnetic resonance imagingOlfactory receptor neuronsNasal polyposisTrigeminal sensitivityNasal mucosaRespiratory epitheliumClinical observationsCerebral activationTrigeminal stimuliOlfactory epitheliumNasal airflowResonance imagingReceptor neuronsStimulus intensityElectro-olfactogramStimulation techniquesRetronasal routePresentationCertain odorsEpitheliumEvent-related potentials