2006
Proteome analysis of mitochondrial outer membrane from Neurospora crassa
Schmitt S, Prokisch H, Schlunck T, Camp DG, Ahting U, Waizenegger T, Scharfe C, Meitinger T, Imhof A, Neupert W, Oefner PJ, Rapaport D. Proteome analysis of mitochondrial outer membrane from Neurospora crassa. Proteomics 2006, 6: 72-80. PMID: 16294304, DOI: 10.1002/pmic.200402084.Peer-Reviewed Original ResearchConceptsMitochondrial outer membraneOuter membraneOuter membrane vesiclesNeurospora crassaImport machineryEukaryotic cellsGenetic systemOMV proteinsBiosynthetic pathwayProteomic studiesNovel functionProteome analysisIntracellular locationMembrane vesiclesTryptic peptide digestsProteinCrassaNumerous interactionsGel electrophoresisPeptide digestsLC-MS/MSMembraneProteomeOrganellesMitochondriaMitoP2: the mitochondrial proteome database—now including mouse data
Prokisch H, Andreoli C, Ahting U, Heiss K, Ruepp A, Scharfe C, Meitinger T. MitoP2: the mitochondrial proteome database—now including mouse data. Nucleic Acids Research 2006, 34: d705-d711. PMID: 16381964, PMCID: PMC1347489, DOI: 10.1093/nar/gkj127.Peer-Reviewed Original ResearchConceptsMitochondrial proteinsSystematic genome-wide studiesMitochondrial proteome databaseNovel mitochondrial proteinGenome-wide studiesSystems biology approachOrthologous proteinsMolecular functionsBiology approachProteome databaseRare mitochondrial diseaseMitochondrial diseasePhenotype screeningMitochondrial dysfunctionReference proteinProteinMitochondriaMouse dataMitoP2ProteomicsIntegration of dataYeastGenesSpeciesPathway
2004
MitoP2, an integrated database on mitochondrial proteins in yeast and man
Andreoli C, Prokisch H, Hörtnagel K, Mueller JC, Münsterkötter M, Scharfe C, Meitinger T. MitoP2, an integrated database on mitochondrial proteins in yeast and man. Nucleic Acids Research 2004, 32: d459-d462. PMID: 14681457, PMCID: PMC308871, DOI: 10.1093/nar/gkh137.Peer-Reviewed Original ResearchConceptsMitochondrial proteinsProtein-protein interactionsMitochondrial proteomeHuman mitochondriopathiesMutant screeningHuman proteinsProteome mappingExpression profilingGenetic characterizationYeastProteinComputational predictionsSearch toolsMitoP2ProteomeReference setComprehensive listProfilingSequenceMitochondriopathy
2003
Role of duplicate genes in genetic robustness against null mutations
Gu Z, Steinmetz LM, Gu X, Scharfe C, Davis RW, Li WH. Role of duplicate genes in genetic robustness against null mutations. Nature 2003, 421: 63-66. PMID: 12511954, DOI: 10.1038/nature01198.Peer-Reviewed Original ResearchConceptsDuplicate genesGenetic robustnessNull mutationSevere fitness effectsGenome-wide evaluationAlternative metabolic pathwaysFitness effectsLoss of functionSequence similarityRegulatory networksDeletion mutantsS. cerevisiaeGenesMetabolic pathwaysDuplicate copiesGene deletionFunctional compensationFitness dataCopiesMutationsMutantsCerevisiaeRelative importanceOrganismsSecond mechanism
2000
MITOP, the mitochondrial proteome database: 2000 update
Scharfe C, Zaccaria P, Hoertnagel K, Jaksch M, Klopstock T, Dembowski M, Lill R, Prokisch H, Gerbitz KD, Neupert W, Mewes HW, Meitinger T. MITOP, the mitochondrial proteome database: 2000 update. Nucleic Acids Research 2000, 28: 155-158. PMID: 10592209, PMCID: PMC102491, DOI: 10.1093/nar/28.1.155.Peer-Reviewed Original ResearchConceptsGene catalogProtein entriesComplete yeast genomeHuman diseasesMitochondrial-encoded proteinsMitochondrial proteome databaseNew mitochondrial proteinsMitochondrial proteomeYeast genomeCaenorhabditis elegansProtein catalogueMitochondrial proteinsEST hitsNeurospora crassaProteome databaseHomology searchSpecies FileMitoPSInterspecies relationshipsFASTA searchGenetic characterizationMus musculusReference sequenceEscherichia coliHomo sapiens