2016
Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner
Mundra J, Jian J, Bhagat P, Liu C. Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner. Scientific Reports 2016, 6: 21115. PMID: 26892362, PMCID: PMC4759551, DOI: 10.1038/srep21115.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesChemokine CXCL10Chemokine CXCL9Cluster AnalysisDermatitis, ContactGene Expression ProfilingGene Expression RegulationIntercellular Signaling Peptides and ProteinsMacrophagesMiceMice, KnockoutProgranulinsReceptors, Tumor Necrosis Factor, Type IRecombinant ProteinsConceptsWild-type B6 micePGRN KO miceRecombinant PGRN proteinTNFR1-dependent mannerSeverity of inflammationInflammatory bowel diseaseAnti-inflammatory functionalityCXCL9 expressionTreg populationGene array analysisBowel diseaseDermatitis modelRheumatoid arthritisChemokine expressionChemokines CXCL9Autoimmune diseasesB6 micePGRN functionCXCL10 expressionKO miceT cellsPleiotrophic growth factorsImmune systemProgranulinNull mice
2008
p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiation
Luan Y, Lengyel P, Liu CJ. p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiation. Cytokine & Growth Factor Reviews 2008, 19: 357-369. PMID: 19027346, PMCID: PMC4442486, DOI: 10.1016/j.cytogfr.2008.11.002.Peer-Reviewed Original ResearchConceptsP200-family proteinsFamily proteinsAmino acid-long C-terminal domainLong C-terminal domainTissue-specific transcription factorsCell proliferationInterferon-inducible p200 familyTissue differentiationC-terminal domainMurine memberRas proteinsSubcellular compartmentsTranscription factorsHuman proteinsMultifunctional regulatorHomologous mouseTarget proteinsProteinTarget activityDifferentiationP204ProliferationTumor growthImportant roleFamily