Featured Publications
ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis
Lai Y, Bai X, Zhao Y, Tian Q, Liu B, Lin E, Chen Y, Lee B, Appleton C, Beier F, Yu X, Liu C. ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis. Annals Of The Rheumatic Diseases 2013, 73: 1575. PMID: 23928557, PMCID: PMC4418017, DOI: 10.1136/annrheumdis-2013-203561.Peer-Reviewed Original ResearchConceptsADAMTS-7ADAMTS-7 expressionRat OA modelPathogenesis of osteoarthritisNF-κB signalingOA modelOA progressionCartilage degradationOA-like phenotypeTumor necrosis factorProgression of osteoarthritisJoint degenerative diseaseDownstream NF-κB signalingPotential molecular targetsPositive feedback loopShort-limbed dwarfismDisease progressionOA developmentNecrosis factorSafranin O stainingYoung miceUpregulated TNFReporter gene assayOsteoarthritisTransgenic miceThe Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ. The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice. Science 2011, 332: 478-484. PMID: 21393509, PMCID: PMC3104397, DOI: 10.1126/science.1199214.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnimalsAnti-Inflammatory Agents, Non-SteroidalArthritis, ExperimentalCartilage, ArticularFemaleGranulinsHumansIntercellular Signaling Peptides and ProteinsLigandsMaleMiceMice, Inbred StrainsMice, KnockoutMice, TransgenicMiddle AgedProgranulinsProtein Interaction Domains and MotifsReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIRecombinant Fusion ProteinsRecombinant ProteinsSignal TransductionT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaYoung AdultConceptsInflammatory arthritisAdministration of progranulinAntagonist of TNFαCollagen-induced arthritisArthritis mouse modelPGRN-deficient miceNew potential therapeutic interventionsPotential therapeutic interventionsGrowth factor progranulinNecrosis factor receptorRheumatoid arthritisMouse modelArthritisTherapeutic interventionsProgranulinTNF receptorFactor receptorMiceReceptorsInflammationTissue repairTNFαIntracellular signalingAtsttrinTNFRAssociation Between Progranulin and Gaucher Disease
Jian J, Zhao S, Tian QY, Liu H, Zhao Y, Chen WC, Grunig G, Torres PA, Wang BC, Zeng B, Pastores G, Tang W, Sun Y, Grabowski GA, Kong MX, Wang G, Chen Y, Liang F, Overkleeft HS, Saunders-Pullman R, Chan GL, Liu CJ. Association Between Progranulin and Gaucher Disease. EBioMedicine 2016, 11: 127-137. PMID: 27515686, PMCID: PMC5049935, DOI: 10.1016/j.ebiom.2016.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesAnimalsCase-Control StudiesDisease Models, AnimalEnzyme ActivationFemaleGaucher DiseaseGene FrequencyGenetic Association StudiesGenotypeHumansIntercellular Signaling Peptides and ProteinsLysosomesMaleMiceMice, KnockoutMiddle AgedMutationPhenotypePolymorphism, Single NucleotideProgranulinsProtein TransportConceptsGD patientsHealthy controlsGaucher diseaseGRN genePGRN KO miceSerum PGRN levelsPGRN-deficient miceHealthy control samplesSerum levelsPGRN levelsGaucher-like cellsKO miceTherapeutic effectRecombinant PGRNGeneral populationPatientsAnimal modelsBone marrowGBA1 geneLysosomal localizationProgranulin geneNull micePGRNDiseaseMice
2019
Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice
Wang C, Zhang L, Ndong J, Hettinghouse A, Sun G, Chen C, Zhang C, Liu R, Liu C. Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice. Journal Of Neuroinflammation 2019, 16: 238. PMID: 31775776, PMCID: PMC6882111, DOI: 10.1186/s12974-019-1630-1.Peer-Reviewed Original ResearchConceptsBasso Mouse ScaleNeurological recoverySpinal cord injuryCord injuryWestern blottingWild-type littermate miceMacrophages/microgliaPromising therapeutic approachWeight-drop techniqueNew therapeutic targetsHuge economic burdenPro-apoptotic effectsPLGA thermosensitive hydrogelFunctional recoveryPGRN deficiencyPGRN expressionLittermate miceIntrathecal spaceProgranulin deficiencyTherapeutic approachesTherapeutic targetEconomic burdenWT controlsDay 21Day 7
2012
Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA
Lai Y, Yu X, Zhang Y, Tian Q, Song H, Mucignat M, Perris R, Samuels J, Krasnokutsky S, Attur M, Greenberg J, Abramson S, Di Cesare P, Liu C. Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA. Osteoarthritis And Cartilage 2012, 20: 854-862. PMID: 22595227, PMCID: PMC3389204, DOI: 10.1016/j.joca.2012.05.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntirheumatic AgentsArthritis, ExperimentalArthritis, RheumatoidCartilage Oligomeric Matrix ProteinCase-Control StudiesEnzyme-Linked Immunosorbent AssayExtracellular Matrix ProteinsFemaleGlycoproteinsHumansMaleMatrilin ProteinsMethotrexateMiceMice, TransgenicMiddle AgedOsteoarthritisRecombinant Fusion ProteinsSynovial FluidTumor Necrosis Factor-alphaYoung AdultConceptsCollagen-induced arthritisEnzyme-linked immunosorbent assayCapture enzyme-linked immunosorbent assayCOMP fragmentsRA patientsOA patientsRheumatoid arthritisRodent arthritis modelsTherapeutic response predictorsArthritis mouse modelSera of patientsTNF-transgenic miceTransgenic animal modelsEffects of interventionsNovel sandwich enzyme-linked immunosorbent assayAnimal disease modelsSandwich enzyme-linked immunosorbent assayDisease courseSerum levelsArthritis modelTNFα inhibitorsArthritic patientsCOMP levelsMurine modelResponse predictors
2008
p204 Protein Overcomes the Inhibition of Core Binding Factor α-1–mediated Osteogenic Differentiation by Id Helix-Loop-Helix Proteins
Luan Y, Yu X, Yang N, Frenkel S, Chen L, Liu C. p204 Protein Overcomes the Inhibition of Core Binding Factor α-1–mediated Osteogenic Differentiation by Id Helix-Loop-Helix Proteins. Molecular Biology Of The Cell 2008, 19: 2113-2126. PMID: 18287524, PMCID: PMC2366862, DOI: 10.1091/mbc.e07-10-1057.Peer-Reviewed Original ResearchMeSH KeywordsAlkaline PhosphataseAmino Acid SequenceAnimalsBone Morphogenetic Protein 2Bone Morphogenetic ProteinsCell DifferentiationCell LineCell NucleusCore Binding Factor alpha SubunitsFemaleHelix-Loop-Helix MotifsHumansInhibitor of Differentiation ProteinsMiceMice, Inbred BALB CNuclear Export SignalsNuclear ProteinsOsteoblastsOsteocalcinOsteogenesisPhosphoproteinsPromoter Regions, GeneticProteasome Endopeptidase ComplexProtein BindingProtein TransportTransforming Growth Factor betaUbiquitinConceptsD proteinsOsteogenic differentiationSequence-specific bindingUbiquitin-proteasome pathwayCore binding factor αExpression of Cbfa1Factor alpha 1P204 proteinExport signalHelix proteinsHelix-LoopRegulatory circuitsTarget genesInterferon-inducible proteinOsteocalcin geneMolecular mechanismsALP activityOsteoblast differentiationDiminished transcriptionCytoplasmic translocationId2Cbfa1Differentiation proteinProteinAlkaline phosphatase
2007
RbAp48 Is a Critical Mediator Controlling the Transforming Activity of Human Papillomavirus Type 16 in Cervical Cancer*
Kong L, Yu X, Bai X, Zhang W, Zhang Y, Zhao W, Jia J, Tang W, Zhou Y, Liu C. RbAp48 Is a Critical Mediator Controlling the Transforming Activity of Human Papillomavirus Type 16 in Cervical Cancer*. Journal Of Biological Chemistry 2007, 282: 26381-26391. PMID: 17616526, DOI: 10.1074/jbc.m702195200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCaspase 3Caspase 8Cell Line, TransformedCell Line, TumorCell Transformation, ViralCellular SenescenceCyclin DCyclinsElectrophoresis, Gel, Two-DimensionalFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHeLa CellsHuman papillomavirus 16HumansMiceMice, NudeNeoplasm TransplantationNuclear ProteinsOncogene Proteins, ViralPapillomavirus E7 ProteinsPhenotypeProto-Oncogene Proteins c-mycRepressor ProteinsRetinoblastoma ProteinRetinoblastoma-Binding Protein 4RNA, Small InterferingTumor Suppressor Protein p53Uterine Cervical DysplasiaUterine Cervical NeoplasmsConceptsCervical cancerH8 cellsCyclin D1Critical mediatorHuman papillomavirus infectionCervical cancer CaSki cellsTumor formationCervical cancer-derived cell linesCervical intraepithelial neoplasiaHuman papillomavirus type 16Papillomavirus type 16Cancer-derived cell linesSenescence-like phenotypePapillomavirus infectionIntraepithelial neoplasiaEnzyme caspase-3Cervical carcinogenesisType 16Nude miceCaSki cellsCancerTumor suppressor retinoblastomaOncogenic genesProtein 4Cell proliferation
2005
Serum Interleukin-6 as a Marker of Periprosthetic Infection Following Total Hip and Knee Arthroplasty
Di Cesare P, Chang E, Preston C, Liu C. Serum Interleukin-6 as a Marker of Periprosthetic Infection Following Total Hip and Knee Arthroplasty. Journal Of Bone And Joint Surgery 2005, 87: 1921-1927. PMID: 16140805, DOI: 10.2106/jbjs.d.01803.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overArthroplasty, Replacement, HipArthroplasty, Replacement, KneeBiomarkersBlood SedimentationCase-Control StudiesC-Reactive ProteinFemaleHumansInterleukin-6Leukocyte CountMaleMiddle AgedPredictive Value of TestsProspective StudiesProsthesis-Related InfectionsSensitivity and SpecificityStatistics, NonparametricConceptsSerum interleukin-6 levelsWhite blood cell countInterleukin-6 levelsErythrocyte sedimentation rateBlood cell countImplant-related problemsTotal hipTotal knee arthroplastyPeriprosthetic infectionSerum levelsNegative predictive valuePositive predictive valueKnee arthroplastyPredictive valueInterleukin-6Elevated serum interleukin-6 levelsC-reactive protein serum levelsTotal knee arthroplasty groupC-reactive protein levelsInterleukin-6 serum levelsKnee arthroplasty groupSerum interleukin-6Group of patientsProtein serum levelsC-reactive protein