Featured Publications
Association Between Progranulin and Gaucher Disease
Jian J, Zhao S, Tian QY, Liu H, Zhao Y, Chen WC, Grunig G, Torres PA, Wang BC, Zeng B, Pastores G, Tang W, Sun Y, Grabowski GA, Kong MX, Wang G, Chen Y, Liang F, Overkleeft HS, Saunders-Pullman R, Chan GL, Liu CJ. Association Between Progranulin and Gaucher Disease. EBioMedicine 2016, 11: 127-137. PMID: 27515686, PMCID: PMC5049935, DOI: 10.1016/j.ebiom.2016.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesAnimalsCase-Control StudiesDisease Models, AnimalEnzyme ActivationFemaleGaucher DiseaseGene FrequencyGenetic Association StudiesGenotypeHumansIntercellular Signaling Peptides and ProteinsLysosomesMaleMiceMice, KnockoutMiddle AgedMutationPhenotypePolymorphism, Single NucleotideProgranulinsProtein TransportConceptsGD patientsHealthy controlsGaucher diseaseGRN genePGRN KO miceSerum PGRN levelsPGRN-deficient miceHealthy control samplesSerum levelsPGRN levelsGaucher-like cellsKO miceTherapeutic effectRecombinant PGRNGeneral populationPatientsAnimal modelsBone marrowGBA1 geneLysosomal localizationProgranulin geneNull micePGRNDiseaseMice
2012
Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA
Lai Y, Yu X, Zhang Y, Tian Q, Song H, Mucignat M, Perris R, Samuels J, Krasnokutsky S, Attur M, Greenberg J, Abramson S, Di Cesare P, Liu C. Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA. Osteoarthritis And Cartilage 2012, 20: 854-862. PMID: 22595227, PMCID: PMC3389204, DOI: 10.1016/j.joca.2012.05.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntirheumatic AgentsArthritis, ExperimentalArthritis, RheumatoidCartilage Oligomeric Matrix ProteinCase-Control StudiesEnzyme-Linked Immunosorbent AssayExtracellular Matrix ProteinsFemaleGlycoproteinsHumansMaleMatrilin ProteinsMethotrexateMiceMice, TransgenicMiddle AgedOsteoarthritisRecombinant Fusion ProteinsSynovial FluidTumor Necrosis Factor-alphaYoung AdultConceptsCollagen-induced arthritisEnzyme-linked immunosorbent assayCapture enzyme-linked immunosorbent assayCOMP fragmentsRA patientsOA patientsRheumatoid arthritisRodent arthritis modelsTherapeutic response predictorsArthritis mouse modelSera of patientsTNF-transgenic miceTransgenic animal modelsEffects of interventionsNovel sandwich enzyme-linked immunosorbent assayAnimal disease modelsSandwich enzyme-linked immunosorbent assayDisease courseSerum levelsArthritis modelTNFα inhibitorsArthritic patientsCOMP levelsMurine modelResponse predictors
2005
Serum Interleukin-6 as a Marker of Periprosthetic Infection Following Total Hip and Knee Arthroplasty
Di Cesare P, Chang E, Preston C, Liu C. Serum Interleukin-6 as a Marker of Periprosthetic Infection Following Total Hip and Knee Arthroplasty. Journal Of Bone And Joint Surgery 2005, 87: 1921-1927. PMID: 16140805, DOI: 10.2106/jbjs.d.01803.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overArthroplasty, Replacement, HipArthroplasty, Replacement, KneeBiomarkersBlood SedimentationCase-Control StudiesC-Reactive ProteinFemaleHumansInterleukin-6Leukocyte CountMaleMiddle AgedPredictive Value of TestsProspective StudiesProsthesis-Related InfectionsSensitivity and SpecificityStatistics, NonparametricConceptsSerum interleukin-6 levelsWhite blood cell countInterleukin-6 levelsErythrocyte sedimentation rateBlood cell countImplant-related problemsTotal hipTotal knee arthroplastyPeriprosthetic infectionSerum levelsNegative predictive valuePositive predictive valueKnee arthroplastyPredictive valueInterleukin-6Elevated serum interleukin-6 levelsC-reactive protein serum levelsTotal knee arthroplasty groupC-reactive protein levelsInterleukin-6 serum levelsKnee arthroplasty groupSerum interleukin-6Group of patientsProtein serum levelsC-reactive protein