2022
Alloimmunization following antigen‐negative red blood cell transfusion
Jacobs J, Binns T, Abels E, Iyer K, Villalba C, Verma A, Sostin N, Tormey C. Alloimmunization following antigen‐negative red blood cell transfusion. Transfusion 2022, 63: 430-434. PMID: 36458330, DOI: 10.1111/trf.17208.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsBlood Group AntigensBlood TransfusionErythrocyte TransfusionErythrocytesFemaleHumansIsoantibodiesPregnancyConceptsTransfusion of RBCsRed blood cell transfusionRed blood cell alloimmunizationPrevious antigen exposureBlood cell transfusionAlloantibody specificitiesCell transfusionRBC transfusionAntigen exposureRBC alloantibodiesAntigenic stimulusDetectable titersAntigenic stimulationMyeloid neoplasmsTransfusionAlloantibodiesAlloimmunizationParticular antigenPrior exposureStimulatory eventsExact mechanismCorresponding antibodiesRBCsExposurePregnancyCan transfusion-associated graft-versus-host disease (TA-GvHD) be prevented with leukoreduction alone?
Rodriguez JV, Tormey CA. Can transfusion-associated graft-versus-host disease (TA-GvHD) be prevented with leukoreduction alone? Transfusion And Apheresis Science 2022, 61: 103402. PMID: 35288056, DOI: 10.1016/j.transci.2022.103402.Peer-Reviewed Original ResearchMeSH KeywordsBlood TransfusionGraft vs Host DiseaseHumansLeukocyte CountLeukocytesTransfusion ReactionConceptsTransfusion-associated graftTA-GVHDHost diseaseCellular blood productsHigh mortality rateWhite blood cellsBlood productsEffective treatmentMortality rateTransfusion communityHigh mortalityMedical literatureBlood cellsDiseaseDevastating diseaseGraftLeukocytesLeukoreductionQuantitative reductionHospitalMortality
2021
Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III)
Goel R, Nellis ME, Karam O, Hanson SJ, Tormey CA, Patel RM, Birch R, Sachais BS, Sola‐Visner M, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Study‐IV‐Pediatric F. Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III). Transfusion 2021, 61: 2589-2600. PMID: 34455598, DOI: 10.1111/trf.16626.Peer-Reviewed Original ResearchConceptsInternational normalized ratioBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIINational Heart LungTransfusion practicePediatric oncologyRecipient EpidemiologyHSCT patientsPlasma transfusionRed blood cellsPlatelet countHeart LungHematopoietic stem cell transplantation patientsHematopoietic stem cell transplant patientsMedian international normalized ratioStem cell transplant patientsStem cell transplantation patientsLower INR valuesPre-transfusion HbMedian platelet countMulticenter retrospective studyCell transplant patientsCell transplantation patientsStudy IIIAcute myeloid leukemia
2020
Patient monitoring during transfusion: Does computerization hold the key to improving an age‐old practice?
Gehrie EA, Tormey CA. Patient monitoring during transfusion: Does computerization hold the key to improving an age‐old practice? Transfusion 2020, 60: 1888-1890. PMID: 33460168, DOI: 10.1111/trf.16030.Peer-Reviewed Original ResearchMeSH KeywordsBlood TransfusionElectronicsHumansMonitoring, PhysiologicTransfusion ReactionVital SignsPreventing transfusion‐associated graft‐versus‐host disease with blood component irradiation: indispensable guidance for a deadly disorder
Loingsigh S, Flegel WA, Hendrickson JE, Tormey CA. Preventing transfusion‐associated graft‐versus‐host disease with blood component irradiation: indispensable guidance for a deadly disorder. British Journal Of Haematology 2020, 191: 653-657. PMID: 32738068, PMCID: PMC9128360, DOI: 10.1111/bjh.17016.Peer-Reviewed Original ResearchTransfusion Service Response to the COVID-19 Pandemic
Gehrie E, Tormey CA, Sanford KW. Transfusion Service Response to the COVID-19 Pandemic. American Journal Of Clinical Pathology 2020, 154: 280-285. PMID: 32584950, PMCID: PMC7449374, DOI: 10.1093/ajcp/aqaa111.Peer-Reviewed Original ResearchInvestigation of increased platelet alloimmunization screening in the era of pathogen‐reduced platelets treated with psoralen/UV light
Hendrickson JE, Mendoza H, Ross R, Siddon AJ, Gowda L, Hauser RG, Schulz WL, Tormey CA. Investigation of increased platelet alloimmunization screening in the era of pathogen‐reduced platelets treated with psoralen/UV light. Transfusion 2020, 60: 650-651. PMID: 32128834, DOI: 10.1111/trf.15691.Peer-Reviewed Original Research
2019
TRIX with treats: the considerable safety benefits of a transfusion medicine registry
Hauser RG, Hendrickson JE, Tormey CA. TRIX with treats: the considerable safety benefits of a transfusion medicine registry. Transfusion 2019, 59: 2489-2492. PMID: 31374148, DOI: 10.1111/trf.15449.Peer-Reviewed Original Research
2018
Delayed haemolytic and serologic transfusion reactions
Siddon AJ, Kenney BC, Hendrickson JE, Tormey CA. Delayed haemolytic and serologic transfusion reactions. Current Opinion In Hematology 2018, 25: 459-467. PMID: 30124474, DOI: 10.1097/moh.0000000000000462.Peer-Reviewed Original ResearchConceptsSickle cell diseaseAdverse eventsTransfusion reactionsTransfusion-associated adverse eventsHaemolytic transfusion reactionsSerologic transfusion reactionsGeneral patient groupNovel immunosuppressive agentPractical preventive strategiesEvidence-based approachImmune dysregulationImmunosuppressive agentsPatient groupTransfusion recipientsRisk factorsBasic epidemiologyCell diseasePreventive strategiesRed blood cell deathAntibody detectionDHTRHaemolytic reactionsMultitude of reportsCell deathDHTRsRhesus pieces: genotype matching of RBCs
Hendrickson JE, Tormey CA. Rhesus pieces: genotype matching of RBCs. Blood 2018, 132: 1091-1093. PMID: 30213839, PMCID: PMC6137558, DOI: 10.1182/blood-2018-07-865634.Peer-Reviewed Original ResearchA Cluster of Cases of Babesia microti Among Neonates Traced to a Single Unit of Donor Blood
Glanternik JR, Baine IL, Rychalsky MR, Tormey CA, Shapiro ED, Baltimore RS. A Cluster of Cases of Babesia microti Among Neonates Traced to a Single Unit of Donor Blood. The Pediatric Infectious Disease Journal 2018, 37: 269-271. PMID: 28945680, DOI: 10.1097/inf.0000000000001803.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitHigh-grade parasitemiaTransfusion-transmitted babesiosisIntensive care unitCluster of casesBlood transfusionPremature infantsCare unitExchange transfusionDonor bloodInfantsBabesia microtiTransfusionBabesiosisNeonatesParasitemiaAzithromycinCliniciansAtovaquoneSingle unitBlood
2016
Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice
Liu J, Santhanakrishnan M, Natarajan P, Gibb DR, Eisenbarth SC, Tormey CA, Siddon AJ, Stowell SR, Branch DR, Hendrickson JE. Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice. Blood 2016, 128: 3159-3168. PMID: 27688803, PMCID: PMC5201095, DOI: 10.1182/blood-2016-06-724732.Peer-Reviewed Original ResearchConceptsMechanism of actionKO miceRed blood cell alloimmunizationGlycoprotein antigenMurine RBCsHuman KEL glycoproteinRh immune globulinSingle knockout miceWild-type recipientsImmunoprophylaxis programKO recipientsPrevent alloimmunizationImmune globulinSerious complicationsAntigen modulationMurine modelImmunoprophylaxisFcγ receptorsKEL antigenAlloimmunizationFlow cytometryRapid clearanceWestern blotMiceAntigenClinically significant anti‐KEL RBC alloantibodies are transferred by breast milk in a murine model
Santhanakrishnan M, Tormey CA, Natarajan P, Liu J, Hendrickson JE. Clinically significant anti‐KEL RBC alloantibodies are transferred by breast milk in a murine model. Vox Sanguinis 2016, 111: 79-87. PMID: 26950259, PMCID: PMC4938760, DOI: 10.1111/vox.12387.Peer-Reviewed Original ResearchConceptsBreast milkRBC alloantibodiesIgA antibodiesMurine modelHuman KEL glycoproteinSeries of pregnanciesBreast milk transferHuman breast milkWild-type pupsKEL RBCsNursing infantsClinical significanceAlloantibodiesNursing pupsMurine dataTransfusion experimentsMilk transferInfantsPupsTransfusionHuman dataSequelaePregnancyAnemiaPremature clearance
2015
Molecular immunohaematology round table discussions at the AABB Annual Meeting, Philadelphia 2014.
Flegel WA, De Castilho SL, Keller MA, Klapper EB, Moulds JM, Noizat-Pirenne F, Shehata N, Stack G, St-Louis M, Tormey CA, Waxman DA, Weinstock C, Wendel S, Denomme GA. Molecular immunohaematology round table discussions at the AABB Annual Meeting, Philadelphia 2014. Blood Transfusion = Trasfusione Del Sangue 2015, 14: 425-33. PMID: 26710354, PMCID: PMC5016302, DOI: 10.2450/2015.0130-15.Peer-Reviewed Original Research
2014
Molecular immunohaematology round table discussions at the AABB Annual Meeting, Denver 2013.
Flegel WA, Castilho L, Delaney M, Klapper EB, Moulds JM, Noizat-Pirenne F, Shehata N, Stack G, Tormey CA, Wagner FF, Waxman DA, Weinstock C, Wendel S, Denomme GA. Molecular immunohaematology round table discussions at the AABB Annual Meeting, Denver 2013. Blood Transfusion = Trasfusione Del Sangue 2014, 13: 514-20. PMID: 25545874, PMCID: PMC4614304, DOI: 10.2450/2014.0213-14.Peer-Reviewed Original ResearchThe Development and Implementation of, and First Years' Experience With, a Massive/Emergency Transfusion Protocol (Damage Control Hematology Protocol) in a Veterans Affairs Hospital
Gehrie EA, Tormey CA. The Development and Implementation of, and First Years' Experience With, a Massive/Emergency Transfusion Protocol (Damage Control Hematology Protocol) in a Veterans Affairs Hospital. Military Medicine 2014, 179: 1099-1105. PMID: 25269127, DOI: 10.7205/milmed-d-14-00045.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBlood BanksBlood Grouping and CrossmatchingBlood Loss, SurgicalBlood TransfusionClinical AuditClinical ProtocolsConnecticutEmergenciesErythrocyte TransfusionFactor VIIaFactor VIIIFibrinogenHematemesisHospitals, VeteransHumansLaboratories, HospitalMalePlasma ExchangePlatelet TransfusionPostoperative HemorrhageRetrospective StudiesUnited StatesUnited States Department of Veterans AffairsConceptsFresh frozen plasmaRecombinant factor VIIaRed blood cellsVeterans Affairs hospitalTransfusion protocolFactor VIIaUnits of RBCsVeterans Affairs Connecticut Healthcare SystemUnits of FFPLarge trauma centersHospital-based blood banksETP patientsMassive transfusionTrauma centerFrozen plasmaSeparate patientsPatientsWest HavenBleeding emergenciesBlood bankBlood cellsYears' experienceHealthcare systemPlateletsHospital
2012
The transfusion medicine specialist as a coagulation consultant: a new variant of therapeutic pathology
Tormey CA, Smith BR. The transfusion medicine specialist as a coagulation consultant: a new variant of therapeutic pathology. Transfusion 2012, 53: 2086-2093. PMID: 23228202, DOI: 10.1111/trf.12012.Peer-Reviewed Original ResearchConceptsTransfusion medicine practitionersMedicine practitionersTransfusion medicineLaboratory coagulation testingRegular clinical practicePatient managementClinical roleCoagulation testingClinical practiceClinical issuesHemostasisShortage of specialistsField of hemostasisConsultationNovel curriculumMedicineThrombosis
2009
Clinical trials for pathogen reduction in transfusion medicine: A review
McClaskey J, Xu M, Snyder EL, Tormey CA. Clinical trials for pathogen reduction in transfusion medicine: A review. Transfusion And Apheresis Science 2009, 41: 217-225. PMID: 19793679, DOI: 10.1016/j.transci.2009.09.008.Peer-Reviewed Original ResearchConceptsClinical trialsBlood productsDonor screening programsDonor blood productsRisk of transmissionInfective donorsTransfusion recipientsScreening programClinical settingInfectious diseasesTransfusion medicineTesting regimensPI treatmentTrialsScreening assaysRiskPathogensPotential toxicityPromising strategyDetection of pathogensRegimensPathogen reductionSensitive methodDiseaseRecipientsIMMUNOHEMATOLOGY: The characterization and classification of concurrent blood group antibodies
Tormey CA, Stack G. IMMUNOHEMATOLOGY: The characterization and classification of concurrent blood group antibodies. Transfusion 2009, 49: 2709-2718. PMID: 19682334, DOI: 10.1111/j.1537-2995.2009.02337.x.Peer-Reviewed Original ResearchConceptsBlood group antibodiesGroup antibodiesVeterans Affairs Medical CenterAntigenic specificityAlloimmunized individualsConcurrent antibodiesAntibody persistenceTransfusion recordsAntibody screenAlloimmunized patientsTime of disappearanceMedical CenterPatientsBG antibodyStudy designAntibody specificityAntibodiesAlloantibodiesAlloimmunizationAntibody pairsCompatibility testingSpecificityMost cases
2008
Red blood cell alloantibody frequency, specificity, and properties in a population of male military veterans
Tormey CA, Fisk J, Stack G. Red blood cell alloantibody frequency, specificity, and properties in a population of male military veterans. Transfusion 2008, 48: 2069-2076. PMID: 18631165, DOI: 10.1111/j.1537-2995.2008.01815.x.Peer-Reviewed Original ResearchConceptsRBC alloantibodiesMale military veteransDecade of birthMilitary veteransVA careRed blood cell alloantibodiesVeterans Affairs Medical CenterHospital-based patientsPercent of casesLarge male predominanceRace/ethnicityAlloantibody frequenciesAlloantibody specificitiesFrequent alloantibodiesTransfusion historyMale predominanceD alloimmunizationTransfusion recordsHigh prevalenceMedical CenterAlloantibodiesAntibody developmentAlloimmunizationAntiglobulin phasePrevalence