2022
Alloimmunization following antigen‐negative red blood cell transfusion
Jacobs J, Binns T, Abels E, Iyer K, Villalba C, Verma A, Sostin N, Tormey C. Alloimmunization following antigen‐negative red blood cell transfusion. Transfusion 2022, 63: 430-434. PMID: 36458330, DOI: 10.1111/trf.17208.Peer-Reviewed Case Reports and Technical NotesConceptsTransfusion of RBCsRed blood cell transfusionRed blood cell alloimmunizationPrevious antigen exposureBlood cell transfusionAlloantibody specificitiesCell transfusionRBC transfusionAntigen exposureRBC alloantibodiesAntigenic stimulusDetectable titersAntigenic stimulationMyeloid neoplasmsTransfusionAlloantibodiesAlloimmunizationParticular antigenPrior exposureStimulatory eventsExact mechanismCorresponding antibodiesRBCsExposurePregnancy
2018
Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion
Patel SR, Gibb DR, Girard-Pierce K, Zhou X, Rodrigues LC, Arthur CM, Bennett AL, Jajosky RP, Fuller M, Maier CL, Zerra PE, Chonat S, Smith NH, Tormey CA, Hendrickson JE, Stowell SR. Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion. Frontiers In Immunology 2018, 9: 2516. PMID: 30505302, PMCID: PMC6250814, DOI: 10.3389/fimmu.2018.02516.Peer-Reviewed Original ResearchConceptsMZ B cellsMarginal zone B cellsRBC transfusionB cellsKEL RBCsImmune factorsAntibody formationRBC antigensRed blood cell alloimmunizationKey immune factorsSpecific immune compartmentCD4 T cellsFollicular B cellsAlloantibody formationImmune compartmentAntibody responseT cellsTherapeutic modalitiesTransfusionImmunological challengeImmune pathwaysMarginal sinusSplenic compartmentsImmune constituentsAlloimmunization
2017
A novel association between high red blood cell alloimmunization rates and hereditary hemorrhagic telangiectasia
Zheng Y, Pollak J, Henderson K, Hendrickson JE, Tormey CA. A novel association between high red blood cell alloimmunization rates and hereditary hemorrhagic telangiectasia. Transfusion 2017, 58: 775-780. PMID: 29210083, DOI: 10.1111/trf.14451.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaRBC alloimmunization rateAlloimmunization rateHHT patientsRBC transfusionHemorrhagic telangiectasiaRed blood cell transfusionProphylactic antigen matchingBlood cell transfusionTertiary care facilityMultiple arteriovenous malformationsAutosomal dominant disorderCommon alloantibodiesHHT populationCell transfusionSurgical bleedingTransfusion burdenAntigen matchingSpontaneous hemorrhageRetrospective studyMedical recordsArteriovenous malformationsCare facilitiesPatientsDisease pathophysiologyThe impact of vaccination on RBC alloimmunization in a murine model
Natarajan P, Santhanakrishnan M, Tormey CA, Hendrickson JE. The impact of vaccination on RBC alloimmunization in a murine model. Vox Sanguinis 2017, 112: 598-600. PMID: 28597520, PMCID: PMC5575953, DOI: 10.1111/vox.12541.Peer-Reviewed Original ResearchConceptsImmune responseMurine modelRBC alloantibody formationDamage-associated molecular patternsImpact of vaccinationRBC alloimmunizationAlloantibody formationHepB vaccineRBC transfusionAdaptive immunityAnimal modelsAlloimmunizationMolecular patternsVaccineVaccinationFuture studiesResponseTransfusionImmunityIrradiation of Red Blood Cells and Alloimmunization
Tormey CA, Hendrickson JE. Irradiation of Red Blood Cells and Alloimmunization. Lab Medicine 2017, 48: 172-177. PMID: 28340248, DOI: 10.1093/labmed/lmx018.Peer-Reviewed Original ResearchConceptsAlloimmunization rateRBC alloimmunization rateTime of transfusionRBC unit transfusionPostoperative bleedingRed blood cell damageRed blood cellsRBC transfusionCommon diagnosisImmunosuppressive disordersTransfusion recipientsBlood cell damageAnimal modelsStudy subjectsTransfusionControl groupRBC antigensAntibody screeningRBC unitsPatientsBlood cellsCell damageRBCsOxidative damageDiagnosis
2016
Understanding red blood cell alloimmunization triggers
Hendrickson JE, Tormey CA. Understanding red blood cell alloimmunization triggers. Hematology 2016, 2016: 446-451. PMID: 27913514, PMCID: PMC6142457, DOI: 10.1182/asheducation-2016.1.446.Peer-Reviewed Original ResearchConceptsRBC alloimmunizationRed blood cellsRisk factorsBlood cellsWhite blood cellsBlood group antigensPregnancy outcomesAlloantibody formationRBC alloantibodiesRBC transfusionRecipient factorsTransfusion safetyAlloimmunizationAnimal modelsHuman studiesPrevention strategiesDonor plasmaDanger signalsParticular antigenGroup antigensAntigenTransfusionPregnancyNonrespondersCellsDetection rate of blood group alloimmunization based on real‐world testing practices and kinetics of antibody induction and evanescence
Stack G, Tormey CA. Detection rate of blood group alloimmunization based on real‐world testing practices and kinetics of antibody induction and evanescence. Transfusion 2016, 56: 2662-2667. PMID: 27394029, DOI: 10.1111/trf.13704.Peer-Reviewed Original ResearchConceptsAntibody inductionAntibody testingAlloantibody detectionRed blood cell transfusionNon-ABO antibodiesBlood cell transfusionGeneral hospital settingBlood group alloantibodiesDetection rateRBC infusionCell transfusionRBC transfusionAntibody screenDays posttransfusionMismatched transfusionHospital settingTransfusionHemolytic reactionRBC unitsStudy designTesting practicesAlloantibodiesAlloimmunizationPatientsOne-thirdThe Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice
Gibb DR, Calabro S, Liu D, Tormey CA, Spitalnik SL, Zimring JC, Hendrickson JE, Hod EA, Eisenbarth SC. The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice. EBioMedicine 2016, 9: 77-86. PMID: 27345021, PMCID: PMC4972549, DOI: 10.1016/j.ebiom.2016.06.008.Peer-Reviewed Original ResearchConceptsRBC transfusionNLRP3 inflammasomeRed blood cell transfusionInnate immune cell activationPro-inflammatory pathogensMolecular patternsBlood cell transfusionProduction of alloantibodiesTransfusion-associated mortalityImmune cell activationInnate immune stimuliBlood group antigensBone marrow failureAlloantibody productionRBC alloimmunizationAlloantibody responsesCell transfusionAlloimmune responseRed blood cellsABO matchingImmunological factorsInflammatory conditionsLeading causeImmune stimuliEndogenous DAMPBridging channel dendritic cells induce immunity to transfused red blood cells
Calabro S, Gallman A, Gowthaman U, Liu D, Chen P, Liu J, Krishnaswamy JK, Nascimento MS, Xu L, Patel SR, Williams A, Tormey CA, Hod EA, Spitalnik SL, Zimring JC, Hendrickson JE, Stowell SR, Eisenbarth SC. Bridging channel dendritic cells induce immunity to transfused red blood cells. Journal Of Experimental Medicine 2016, 213: 887-896. PMID: 27185856, PMCID: PMC4886363, DOI: 10.1084/jem.20151720.Peer-Reviewed Original ResearchConceptsSplenic dendritic cellsDendritic cellsRBC transfusionT cellsImmune responseRed blood cell transfusionBlood cell transfusionT cell primingConventional dendritic cellsDetrimental immune responsesB cell responsesNaive T cellsT cell helpMurine transfusion modelRBC transfusion supportTime of transfusionRBC alloantigensCell transfusionDC subsetsAllogeneic RBCsRed blood cellsRenal failureTransfusion supportMajor complicationsCell priming
2015
A Novel Network Analysis Tool to Identify Relationships Between Disease States and Risk for RBC Alloimmunization
Celli R, Schulz W, Hendrickson J, Tormey C. A Novel Network Analysis Tool to Identify Relationships Between Disease States and Risk for RBC Alloimmunization. Blood 2015, 126: 2349. DOI: 10.1182/blood.v126.23.2349.2349.Peer-Reviewed Original ResearchDisease statesControl cohortAcute myeloid leukemia/myelodysplastic syndromeLeukemia/myelodysplastic syndromeRed blood cell alloimmunizationChronic transfusion supportHyper-responder groupAcute renal failureAML/MDSAcute myocardial infarctionICD-9 codesDevelopment of alloantibodiesSpecific medical conditionsElectronic medical recordsSignificant disease associationCertain disease statesAlloimmunized individualsRBC alloimmunizationGastrointestinal bleedPulmonary hypertensionRenal failureTransfusion burdenTransfusion supportMale patientsRBC transfusion
2008
Delayed intravascular haemolysis following multiple asymptomatic ABO‐incompatible red blood cell transfusions in a patient with hepatic failure
Tormey CA, Stack G. Delayed intravascular haemolysis following multiple asymptomatic ABO‐incompatible red blood cell transfusions in a patient with hepatic failure. Vox Sanguinis 2008, 95: 232-235. PMID: 19121188, DOI: 10.1111/j.1423-0410.2008.01085.x.Peer-Reviewed Original ResearchConceptsABO-incompatible red blood cell (RBC) transfusionsRed blood cell transfusionBlood cell transfusionFresh frozen plasmaCell transfusionHepatic failureDelayed Haemolytic Transfusion ReactionAnamnestic antibody responseLow complement levelsHaemolytic transfusion reactionsOnset of haemolysisFirst transfusionRBC transfusionComplement levelsIncompatible transfusionsAntibody responseAntibody titresHepatic diseaseTransfusion reactionsIntravascular haemolysisTransfusionPatientsRBC unitsB RBCsHaemolysis