2021
A neutrophil activation signature predicts critical illness and mortality in COVID-19
Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. A neutrophil activation signature predicts critical illness and mortality in COVID-19. Blood Advances 2021, 5: 1164-1177. PMID: 33635335, PMCID: PMC7908851, DOI: 10.1182/bloodadvances.2020003568.Peer-Reviewed Original ResearchConceptsCritical illnessHealth system databaseNeutrophil activationCOVID-19Neutrophil activation signatureSevere COVID-19Intensive care unitGranulocyte colony-stimulating factorHigh mortality rateColony-stimulating factorSystem databaseHepatocyte growth factorClinical decompensationNeutrophil countImmune hyperactivationCare unitEarly elevationLipocalin-2Interleukin-8Longitudinal cohortClinical dataMortality ratePatientsIllnessActivation signature
2018
Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease.
Won CHJ, Qin L, Selim B, Yaggi HK. Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease. Journal Of Clinical Sleep Medicine 2018, 14: 1987-1994. PMID: 30518445, PMCID: PMC6287733, DOI: 10.5664/jcsm.7520.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaHypopnea definitionsDesaturation criteriaOdds ratioCardiovascular diseaseOSA diagnosisSeverity of OSAModerate obstructive sleep apneaSevere obstructive sleep apneaDifferent hypopnea definitionsLess smoking historySleep-disordered breathingIschemic heart diseaseSignificant risk factorsCross-sectional analysisArousal definitionHypopnea criteriaCardiovascular riskOSA severitySmoking historyHeart failureClinical featuresSleep apneaOSA groupRisk factorsDiagnosing and Treating Sleep Apnea in Patients With Acute Cerebrovascular Disease
Bravata DM, Sico J, Fragoso C, Miech EJ, Matthias MS, Lampert R, Williams LS, Concato J, Ivan CS, Fleck JD, Tobias L, Austin C, Ferguson J, Radulescu R, Iannone L, Ofner S, Taylor S, Qin L, Won C, Yaggi HK. Diagnosing and Treating Sleep Apnea in Patients With Acute Cerebrovascular Disease. Journal Of The American Heart Association 2018, 7: e008841. PMID: 30369321, PMCID: PMC6201384, DOI: 10.1161/jaha.118.008841.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressure usePositive airway pressure useTransient ischemic attackRankin Scale scoreIschemic stroke/transient ischemic attackStroke/transient ischemic attackBackground Obstructive sleep apneaHealth Stroke ScaleIschemic attackScale scoreStroke ScaleIschemic strokeTreat analysisSleep apneaAcute ischemic stroke/transient ischemic attackHealth Stroke Scale scoreNational InstituteContinuous positive airway pressureModified Rankin Scale scoreNeurological functioningNeurological symptom severityRecent ischemic strokeStroke Scale scoreAcute cerebrovascular diseaseAcute ischemic stroke
2016
The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study.
Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.Peer-Reviewed Original ResearchConceptsSleep-disordered breathingNocturnal cardiac arrhythmiasIntraventricular conduction delayApnea-hypopnea indexCardiac arrhythmiasTwo-fold oddsModerate-severe sleep-disordered breathingSeverity of SDBSevere sleep-disordered breathingComplex ventricular ectopyMultiple cardiovascular comorbiditiesObstructive respiratory eventsClinic-based populationCross-sectional analysisCardiovascular comorbiditiesSDB patientsVentricular ectopySDB severityRespiratory eventsUnadjusted oddsSupraventricular tachycardiaCardiovascular diseaseArrhythmia subtypesArrhythmia riskConduction delay
2015
The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods
Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.Peer-Reviewed Original ResearchConceptsCardiovascular outcomesVascular eventsSleep architecturePrognostic modelRetrospective observational cohort studyMain primary outcomeMiddle-aged veteransTransient ischemic attackAcute coronary syndromeObservational cohort studyResultsThe study populationCongestive heart failureSleep-disordered breathingVA Patient Treatment FileVital Status filesPatient Treatment FileComputerized patient record systemVeterans Affairs centersPost-traumatic stress disorderIschemic attackCoronary syndromeCohort studySecondary outcomesComposite endpointGlycemic control
2012
Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury
Won CH, Chun HJ, Chandra SM, Sarinas PS, Chitkara RK, Heidenreich PA. Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury. Sleep And Breathing 2012, 17: 85-91. PMID: 22294346, DOI: 10.1007/s11325-012-0653-y.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina, UnstableBody Mass IndexCause of DeathCohort StudiesComorbidityContinuous Positive Airway PressureEchocardiographyFemaleFollow-Up StudiesHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionMyocardial IschemiaPatient CompliancePolysomnographyPrognosisRiskRisk FactorsSleep Apnea, ObstructiveSurvival AnalysisTroponin IConceptsSevere obstructive sleep apneaObstructive sleep apneaIschemic heart diseaseSleep apneaMyocardial injuryHeart diseaseOSA groupMild-moderate obstructive sleep apneaModerate obstructive sleep apneaPrevious myocardial injuryAdjusted hazard ratioRetrospective cohort studyConsecutive OSA patientsElevated troponin levelsSevere OSA groupRisk of deathDose-dependent impactCohort studyHazard ratioOSA patientsOSA severityTroponin levelsConclusionsThe severityRisk stratificationCardiac patients