2023
Maturation of the malarial phosphatidylserine decarboxylase is mediated by high affinity binding to anionic phospholipids
Choi J, Lopes L, Mamoun C, Voelker D. Maturation of the malarial phosphatidylserine decarboxylase is mediated by high affinity binding to anionic phospholipids. Journal Of Biological Chemistry 2023, 299: 104659. PMID: 36997087, PMCID: PMC10172927, DOI: 10.1016/j.jbc.2023.104659.Peer-Reviewed Original ResearchConceptsPS decarboxylase
2020
An improved and highly selective fluorescence assay for measuring phosphatidylserine decarboxylase activity Fluorescence detection of PS decarboxylase activity
Choi JY, Black R, Lee H, Di Giovanni J, Murphy RC, Ben Mamoun C, Voelker DR. An improved and highly selective fluorescence assay for measuring phosphatidylserine decarboxylase activity Fluorescence detection of PS decarboxylase activity. Journal Of Biological Chemistry 2020, 295: 9211-9222. PMID: 32430397, PMCID: PMC7335775, DOI: 10.1074/jbc.ra120.013421.Peer-Reviewed Original Research
2015
Characterization of Plasmodium phosphatidylserine decarboxylase expressed in yeast and application for inhibitor screening
Choi JY, Kumar V, Pachikara N, Garg A, Lawres L, Toh J, Voelker DR, Ben Mamoun C. Characterization of Plasmodium phosphatidylserine decarboxylase expressed in yeast and application for inhibitor screening. Molecular Microbiology 2015, 99: 999-1014. PMID: 26585333, PMCID: PMC4898484, DOI: 10.1111/mmi.13280.Peer-Reviewed Original ResearchConceptsClass of enzymesDevelopment of antimicrobialsYeast genesMembrane biogenesisEukaryotic pathogensProenzyme processingMammalian cellsPhosphatidylserine decarboxylasePSD activityPhospholipid biosynthesisParasite enzymeEssential functionsGenetic studiesMetabolic analysisAmino acidsDecarboxylase enzymePhosphatidylethanolamine synthesisPosition 40Inhibitor screeningEssential roleYeastEnzymePlasmodium falciparumSuitable targetNovel class