Featured Publications
Babesia duncani multi-omics identifies virulence factors and drug targets
Singh P, Lonardi S, Liang Q, Vydyam P, Khabirova E, Fang T, Gihaz S, Thekkiniath J, Munshi M, Abel S, Ciampossin L, Batugedara G, Gupta M, Lu X, Lenz T, Chakravarty S, Cornillot E, Hu Y, Ma W, Gonzalez L, Sánchez S, Estrada K, Sánchez-Flores A, Montero E, Harb O, Le Roch K, Mamoun C. Babesia duncani multi-omics identifies virulence factors and drug targets. Nature Microbiology 2023, 8: 845-859. PMID: 37055610, PMCID: PMC10159843, DOI: 10.1038/s41564-023-01360-8.Peer-Reviewed Original ResearchConceptsDrug targetsVirulence factorsCandidate virulence factorsRNA-seq dataIntraerythrocytic life cycleAttractive drug targetB. duncaniNuclear genomeGenome annotationApicomplexan parasitesApicomplexan pathogensEpigenetic profilesEpigenetic analysisParasite metabolismMalaria-like diseaseHuman erythrocytesLife cycle stagesBabesia speciesGenomeMetabolic requirementsCycle stagesLife cycleBiologySmall moleculesPotent inhibitor
2017
Antimalarial Properties of Simplified Kalihinol Analogues
Daub ME, Prudhomme J, Mamoun C, Le Roch KG, Vanderwal CD. Antimalarial Properties of Simplified Kalihinol Analogues. ACS Medicinal Chemistry Letters 2017, 8: 355-360. PMID: 28337330, PMCID: PMC5346982, DOI: 10.1021/acsmedchemlett.7b00013.Peer-Reviewed Original ResearchNatural productsIsonitrile functional groupsPrevious total synthesisTotal synthesisFunctional groupsRepresentative compoundsReasonable stabilitySimple analogCompoundsAntimalarial propertiesAntimalarial activityAntimalarial agentsPotent activityAnaloguesInherent liabilitySclareolidePotent inhibitorSynthesisProductsScaffoldsKalihinolsStabilityAgentsProperties