2018
Role of a VGF/BDNF/TrkB Autoregulatory Feedback Loop in Rapid-Acting Antidepressant Efficacy
Jiang C, Lin WJ, Salton SR. Role of a VGF/BDNF/TrkB Autoregulatory Feedback Loop in Rapid-Acting Antidepressant Efficacy. Journal Of Molecular Neuroscience 2018, 68: 504-509. PMID: 30022437, PMCID: PMC6338529, DOI: 10.1007/s12031-018-1124-0.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorRapid-acting antidepressantsTLQP-62Antidepressant efficacyReceptor activationN-methyl-D-aspartate receptorsParticular brain-derived neurotrophic factorIsoxazolepropionic acid receptor (AMPAR) activationBDNF/TrkBDepression-like behaviorRapid antidepressant actionsIntra-hippocampal administrationAMPA receptor activationExpression of VGFChemical antidepressantsAntidepressant actionBDNF expressionSustained efficacyNeurotrophic factorNeurotrophin familySwim testVoluntary exerciseMTOR pathwayMTOR activationAntidepressants
2012
Role of Neurotrophins in the Development and Function of Neural Circuits That Regulate Energy Homeostasis
Fargali S, Sadahiro M, Jiang C, Frick AL, Indall T, Cogliani V, Welagen J, Lin WJ, Salton SR. Role of Neurotrophins in the Development and Function of Neural Circuits That Regulate Energy Homeostasis. Journal Of Molecular Neuroscience 2012, 48: 654-659. PMID: 22581449, PMCID: PMC3480664, DOI: 10.1007/s12031-012-9790-9.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsAutonomic Fibers, PostganglionicBasal MetabolismBrain StemCorticotropin-Releasing HormoneEatingEnergy MetabolismGene Expression RegulationGlucocorticoidsHomeostasisHumansHypothalamusNerve Growth FactorsNeural PathwaysNeuropeptidesReceptors, Nerve Growth FactorSignal TransductionSpinal CordSympathetic Nervous SystemConceptsNeurotrophic growth factorsNeurotrophic factorGrowth factorBrain-derived neurotrophic factorEnergy homeostasisRole of neurotrophinsSympathetic nervous systemPeripheral metabolic tissuesWhite adipose tissueNerve growth factorCiliary neurotrophic factorCentral nervous system developmentNeurotrophin-4/5Neurotrophin-3Neurotrophin familyNeuronal survivalNervous system developmentSpinal cordAdipose tissueNervous systemCircuit formationNeural circuitsMetabolic tissuesEnergy expenditureCritical gene products