Multiple translational isoforms give functional specificity to serum‐ and glucocorticoid‐induced kinase 1 (Sgk1)
Arteaga M, Canessa C. Multiple translational isoforms give functional specificity to serum‐ and glucocorticoid‐induced kinase 1 (Sgk1). The FASEB Journal 2007, 21: a547-a548. DOI: 10.1096/fasebj.21.5.a547-d.Peer-Reviewed Original ResearchN-terminusFunctional specificityEvolutionary distant speciesCore kinase domainFOXO transcriptional factorAlternative translation initiationNumerous cellular processesDifferent cellular compartmentsGlucocorticoid-induced kinase 1Glycogen synthase kinase 3bDiversity of functionsDifferent N-terminiDistant speciesER membraneCellular processesTranslation initiationSingle kinaseCellular compartmentsKinase domainT kinaseTranscriptional factorsDistinct substratesKinase 1ER stressCell survivalMultiple Translational Isoforms Give Functional Specificity to Serum- and Glucocorticoid-induced Kinase 1
Arteaga MF, de la Rosa D, Alvarez JA, Canessa CM. Multiple Translational Isoforms Give Functional Specificity to Serum- and Glucocorticoid-induced Kinase 1. Molecular Biology Of The Cell 2007, 18: 2072-2080. PMID: 17377066, PMCID: PMC1877090, DOI: 10.1091/mbc.e06-10-0968.Peer-Reviewed Original ResearchConceptsFunctional specificityKinase 1Core kinase domainGlycogen synthase kinase-3betaAlternative translation initiationDifferent cellular compartmentsSynthase kinase-3betaGlucocorticoid-induced kinase 1Different N-terminiActivation of SGK1ER membraneTranslation initiationCellular compartmentsKinase domainKinase-3betaUbiquitous kinaseTranscriptional factorsN-terminusDiverse processesEpithelial sodium channelLong isoformShort isoformER stressCell survivalTranslational isoforms