2019
Achievement of Guideline-Recommended Weight Loss Among Patients With Ischemic Stroke and Obesity
Dearborn JL, Viscoli CM, Young LH, Gorman MJ, Furie KL, Kernan WN. Achievement of Guideline-Recommended Weight Loss Among Patients With Ischemic Stroke and Obesity. Stroke 2019, 50: 713-717. PMID: 30786849, PMCID: PMC6391736, DOI: 10.1161/strokeaha.118.024008.Peer-Reviewed Original ResearchConceptsTransient ischemic attackBody mass indexProportion of patientsIschemic strokeMass indexVascular eventsBaseline weightWeight lossAchievement of guidelineDays of randomizationRecent ischemic strokeAcute ischemic strokeFuture vascular eventsIschemic attackPlacebo groupObese patientsDiabetes mellitusMedian ageTrial entryIRIS trialMedian timeFunctional outcomeInsulin resistanceClinical trialsPatients
2018
Scoring System to Optimize Pioglitazone Therapy After Stroke Based on Fracture Risk
Viscoli CM, Kent DM, Conwit R, Dearborn JL, Furie KL, Gorman M, Guarino PD, Inzucchi SE, Stuart A, Young LH, Kernan WN, Investigators F. Scoring System to Optimize Pioglitazone Therapy After Stroke Based on Fracture Risk. Stroke 2018, 50: 95-100. PMID: 30580725, PMCID: PMC6557695, DOI: 10.1161/strokeaha.118.022745.Peer-Reviewed Original ResearchTransient ischemic attackAbsolute risk differenceFracture riskIschemic attackPioglitazone therapyFracture risk modelsIschemic strokeMyocardial infarctionRisk strataRisk differenceRandomized placebo-controlled trialFavorable benefit-risk profilePlacebo-controlled trialLow-risk patientsEffect of pioglitazoneBody mass indexHigh-risk groupBenefit-risk profileHigh-risk stratumLow-risk groupSimple point scoreBone fracture riskCardiovascular riskPatient characteristicsDiabetes mellitus
2016
A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack
Xu J, Viscoli CM, Ford GA, Gorman M, Kernan WN, Investigators I. A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack. Journal Of Stroke And Cerebrovascular Diseases 2016, 25: 1705-1712. PMID: 27080156, PMCID: PMC5749402, DOI: 10.1016/j.jstrokecerebrovasdis.2016.03.043.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedArea Under CurveBiomarkersBlood GlucoseBlood PressureBody Mass IndexBrain IschemiaFemaleGlucose Metabolism DisordersHumansInsulinInsulin ResistanceIschemic Attack, TransientLipoproteins, HDLMaleMiddle AgedMultivariate AnalysisObesity, AbdominalPredictive Value of TestsRandomized Controlled Trials as TopicReproducibility of ResultsRisk FactorsROC CurveSex FactorsStrokeTriglyceridesWaist-Hip RatioConceptsTransient ischemic attackBody mass indexInsulin resistanceMultivariable regression analysisNondiabetic patientsIschemic strokeIschemic attackAbdominal obesityValidation cohortTriglyceride/high-density lipoprotein ratioHigh-density lipoprotein ratioRecent ischemic strokeHomeostasis model assessmentSystolic blood pressureLaboratory test valuesRegression analysisElevated waistHOMA-IRLipoprotein ratioBlood pressureMass indexMultivariable analysisStroke patientsHip ratioMale gender
2003
Major Risk Factors for Aneurysmal Subarachnoid Hemorrhage in the Young Are Modifiable
Broderick JP, Viscoli CM, Brott T, Kernan WN, Brass LM, Feldmann E, Morgenstern LB, Wilterdink JL, Horwitz RI. Major Risk Factors for Aneurysmal Subarachnoid Hemorrhage in the Young Are Modifiable. Stroke 2003, 34: 1375-1381. PMID: 12764233, DOI: 10.1161/01.str.0000074572.91827.f4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionBody Mass IndexCase-Control StudiesCocaine-Related DisordersCohort StudiesComorbidityCooperative BehaviorFemaleHumansHypertensionLogistic ModelsMaleMiddle AgedOdds RatioPhenylpropanolamineRisk FactorsSex DistributionSmokingStrokeSubarachnoid HemorrhageThinnessUnited StatesConceptsAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageRisk factorsLower body mass indexIndependent risk factorCurrent cigarette smokersPrevalent risk factorsBody mass indexMajor risk factorCase-control studyYears of ageRandom digit dialingWarrants further studyHemorrhagic strokeIntracerebral hemorrhageCigarette smokersMass indexPreventable diseaseWomen 18Multivariable modelFamily historyCase subjectsAssociation of caffeineCocaine useHemorrhage