2010
Chapter One Models of Depression
Duman C. Chapter One Models of Depression. Vitamins & Hormones 2010, 82: 1-21. PMID: 20472130, DOI: 10.1016/s0083-6729(10)82001-1.ChaptersConceptsChronic mild stress modelEarly-life stress modelStress exposureAvailable drug treatmentsDepressive-like stateTail suspension testAntidepressant drug responseSignificant health burdenDepressive illnessSwim testHealth burdenDrug treatmentQuantifiable correlatesSuspension testShort-term exposureDisease processAnimal modelsExperimental animalsDepression attemptUncontrollable stressHuman symptomsDrug responseDepressionExposurePredictive validity
2008
Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice
Duman CH, Schlesinger L, Russell DS, Duman RS. Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice. Brain Research 2008, 1199: 148-158. PMID: 18267317, PMCID: PMC2330082, DOI: 10.1016/j.brainres.2007.12.047.Peer-Reviewed Original ResearchMeSH KeywordsAmitriptylineAnalysis of VarianceAnimalsAntidepressive Agents, TricyclicAnxietyBehavior, AnimalBrain-Derived Neurotrophic FactorDepressionDisease Models, AnimalEscape ReactionHelplessness, LearnedMaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutMotor ActivityPain MeasurementPhysical Conditioning, AnimalReaction TimeSwimmingTime FactorsConceptsBrain-derived neurotrophic factorAntidepressant-like behavioral responsesAntidepressant-like behavioral changesHeterozygous BDNF knockout miceBDNF knockout miceAntidepressant drug treatmentAntidepressant-like behaviorWheel-running exerciseDrug-treated animalsWild-type miceAnxiolytic behavioral effectsFST performanceSedentary control miceBDNF mRNASubchronic administrationChronic exerciseControl miceNeurotrophic factorBasic research studiesBehavioral responsesVoluntary exerciseBDNF geneDrug treatmentKnockout miceLocomotor activity