2021
Polyisocyanates and Their Prepolymers
Jolly A, Maestrelli P, Redlich C, Malo J, Bernstein D. Polyisocyanates and Their Prepolymers. 2021, 179-194. DOI: 10.1201/9781003000624-14.ChaptersOccupational asthmaHuman leukocyte antigenAirway inflammationDiisocyanate-induced occupational asthmaSensitizer-induced occupational asthmaWeight agentsOnset of asthmaOnset of symptomsLong-term outcomesMedical surveillance programNon-HLA genesReduction of exposureAverage exposure levelsAirway hyperresponsivenessSevere asthmaAsthmatic symptomsClinical presentationNeutrophilic infiltrateLeukocyte antigenClinical assessmentDifferent exposure metricsIrritant concentrationsHigh riskMechanism of sensitizationIsocyanate exposure
2012
Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG
Wisnewski AV, Stowe MH, Nerlinger A, Opare-addo P, Decamp D, Kleinsmith CR, Redlich CA. Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG. Annals Of Work Exposures And Health 2012, 56: 901-910. PMID: 22449630, PMCID: PMC3471419, DOI: 10.1093/annhyg/mes024.Peer-Reviewed Original ResearchConceptsPersonal protective equipmentSkin exposureExposure surveillanceSpecific serum immunoglobulin GHexamethylene diisocyanate exposureSerum IgG levelsSerum immunoglobulin GNight shift workEnzyme-linked immunosorbentAdverse health effectsAsthma historyDiisocyanate exposureIgG levelsSerum levelsIgG titersChemical allergensPPE useImmune responseRespirator useIsocyanate exposureExposure biomarkersPractical biomarkersBasic demographicsHigh titersHygiene efforts
2006
Respiratory Protection from Isocyanate Exposure in the Autobody Repair and Refinishing Industry
Liu Y, Stowe MH, Bello D, Woskie SR, Sparer J, Gore R, Youngs F, Cullen MR, Redlich CA. Respiratory Protection from Isocyanate Exposure in the Autobody Repair and Refinishing Industry. Journal Of Occupational And Environmental Hygiene 2006, 3: 234-249. PMID: 16574607, DOI: 10.1080/15459620600628704.Peer-Reviewed Original ResearchConceptsWorkplace protection factorsIsocyanate exposureHalf-facepiece respiratorsRespiratory protectionFit factorsRespiratory protection programTotal isocyanate groupRespirator Fit FactorsOrganic vapor cartridgesShort-term exposure limitNegative pressureGM concentrationsPriming activitySignificant differencesExposure limitsUse trainingExposureRespiratorsProtection factorSecond testWorkersPortaCount
2005
Glutathione protects human airway proteins and epithelial cells from isocyanates
Wisnewski AV, Liu Q, Liu J, Redlich CA. Glutathione protects human airway proteins and epithelial cells from isocyanates. Clinical & Experimental Allergy 2005, 35: 352-357. PMID: 15784115, DOI: 10.1111/j.1365-2222.2005.02185.x.Peer-Reviewed Original ResearchConceptsDose-dependent mannerAirway fluidGSH levelsHuman airway epithelial cellsVapor exposure systemEpithelial cellsHuman airway epithelial cell lineAirway epithelial cell lineEpithelial lining fluidAirway epithelial cellsEpithelial cell exposureEpithelial cell toxicityAllergic sensitizationEpithelial cell lineHDI exposureAirway proteinsLining fluidAirway cellsIsocyanate exposureVivo exposureOccupational limitsNCI-H292Physiologic levelsEpithelial fluidToxicity studies
2004
Isocyanate Exposures in Autobody Shop Work: The SPRAY Study
Sparer J, Stowe MH, Bello D, Liu Y, Gore RJ, Youngs F, Cullen MR, Redlich CA, Woskie SR. Isocyanate Exposures in Autobody Shop Work: The SPRAY Study. Journal Of Occupational And Environmental Hygiene 2004, 1: 570-581. PMID: 15559329, DOI: 10.1080/15459620490485909.Peer-Reviewed Original ResearchConceptsIsocyanate exposurePersonal air samplesTypes of glovesRespiratory sensitizationEpidemiologic studiesTypes of respiratorsU.K. guidelinesSkin contactAutobody shopsSubstantial exposureAir respiratorsNational InstituteOccupational SafetyRespiratorsCartridge respiratorsPersonal samplesExposure limitsMedian concentrationsExposureUnited Kingdom HealthSealerHealthGuidelinesPercentAsthma