2007
IGF‐1 stimulates de novo fatty acid biosynthesis by Schwann cells during myelination
Liang G, Cline GW, Macica CM. IGF‐1 stimulates de novo fatty acid biosynthesis by Schwann cells during myelination. Glia 2007, 55: 632-641. PMID: 17299765, DOI: 10.1002/glia.20496.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAnimalsCell CommunicationCells, CulturedCoculture TechniquesFatty AcidsGanglia, SpinalInsulin-Like Growth Factor IMembrane LipidsMyelin SheathNeurons, AfferentPeripheral Nervous SystemPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySchwann CellsSignal TransductionConceptsInsulin-like growth factor-1Fatty acid synthesizing enzymesSynthesizing enzymesIGF-1 treatmentMyelin membrane formationGrowth factor-1PI3K/Akt pathwaySchwann cell differentiationPI3K/AktWestern blot analysisSciatic nerveIGF-1Schwann cellsElectrospray mass spectroscopy analysisCell coculturesMyelin-specific proteinsGrowth factorAkt pathwayMyelinationFactor 1Fatty acid synthesisCocultureBlot analysisEarly eventsMyelin membrane
2006
Induction of parathyroid hormone‐related peptide following peripheral nerve injury: Role as a modulator of Schwann cell phenotype
Macica CM, Liang G, Lankford KL, Broadus AE. Induction of parathyroid hormone‐related peptide following peripheral nerve injury: Role as a modulator of Schwann cell phenotype. Glia 2006, 53: 637-648. PMID: 16470617, DOI: 10.1002/glia.20319.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell DifferentiationCell ProliferationCells, CulturedCyclic AMP Response Element-Binding ProteinDisease Models, AnimalGanglia, SpinalGrowth ConesLigationMiceNerve RegenerationNeurons, AfferentParathyroid Hormone-Related ProteinPeripheral Nerve InjuriesPeripheral NervesRatsRats, Sprague-DawleyReceptor, Parathyroid Hormone, Type 1RNA, MessengerSchwann CellsSciatic NerveSciatic NeuropathyUp-RegulationConceptsSciatic nerve injury modelNerve injury modelPeripheral nerve injuryRole of PTHrPHormone-related peptideSchwann cellsSciatic nerveNerve injuryInjury modelNerve regenerationNervous systemParathyroid hormone-related peptideInjured sciatic nerveDedifferentiated Schwann cellsSchwann cell phenotypeRat nervous systemPeripheral nervous systemPTHrP receptor mRNASuccessful nerve regenerationType 1 collagen matrixSchwann cell culturesSympathetic gangliaPTHrP functionsPTHrP mRNAReceptor mRNA