1993
Characterization of cytochrome P-450-dependent arachidonic acid metabolism in rabbit intestine
Macica C, Balazy M, Falck J, Mioskowski C, Carroll M. Characterization of cytochrome P-450-dependent arachidonic acid metabolism in rabbit intestine. American Journal Of Physiology 1993, 265: g735-g741. PMID: 8238357, DOI: 10.1152/ajpgi.1993.265.4.g735.Peer-Reviewed Original ResearchConceptsEpithelial ion transportAA metabolitesNew Zealand white male rabbitsRegional blood flowArachidonic acid metabolismWhite male rabbitsDuodenal microsomesIleal microsomesMesenteric bedIntestinal functionArachidonate metabolismBW 755CBlood flowHigh-pressure liquid chromatographyEnzyme inhibitorsMale rabbitsAA metabolismIntestinal tractSKF-525ALipoxygenase inhibitorsRabbit intestineMicrosomal activityPresence of NADPHAbsence of NADPHAcid metabolism
1992
Reduced glomerular thromboxane receptor sites and vasoconstrictor responses in diabetic rats
Wilkes B, Kaplan R, Mento P, Aynedjian H, Macica C, Schlondorff D, Bank N. Reduced glomerular thromboxane receptor sites and vasoconstrictor responses in diabetic rats. Kidney International 1992, 41: 992-999. PMID: 1387436, DOI: 10.1038/ki.1992.151.Peer-Reviewed Original ResearchConceptsRenal blood flowGlomerular filtration rateDiabetic ratsThromboxane receptorFiltration rateBlood flowNormal controlsReceptor sitesHigher renal blood flowEuglycemic diabetic ratsHyperglycemic diabetic ratsRenal hemodynamic responseStable thromboxane analogThromboxane synthetase inhibitionUrinary thromboxane excretionInjection of streptozotocinAngiotensin II receptorsThromboxane excretionVasoconstrictor responsesConstrictor responsesDiabetic kidneyEarly diabetesVasoconstrictor receptorsBlood glucoseRats 7
1991
Glomerular endothelin receptors during initiation and maintenance of ischemic acute renal failure in rats
Wilkes B, Pearl A, Mento P, Maita M, Macica C, Girardi E. Glomerular endothelin receptors during initiation and maintenance of ischemic acute renal failure in rats. American Journal Of Physiology 1991, 260: f110-f118. PMID: 1847009, DOI: 10.1152/ajprenal.1991.260.1.f110.Peer-Reviewed Original ResearchConceptsIschemic acute renal failureAcute renal failureRenal blood flowGlomerular filtration rateET receptorsRenal failureEndothelin receptorsET infusionElevated ET levelsLeft renal arteryMean arterial pressureNormal Sprague-Dawley ratsSprague-Dawley ratsReceptor sitesRenal hemodynamicsArterial pressureContralateral kidneyRenal arteryFiltration rateReceptor numberBlood flowET levelsRatsET bindingAdditional studies