2022
Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer’s disease
Wilson E, Young C, Ramos Benitez J, Swarovski M, Feinstein I, Vandijck M, Le Guen Y, Kasireddy N, Shahid M, Corso N, Wang Q, Kennedy G, Trelle A, Lind B, Channappa D, Belnap M, Ramirez V, Skylar-Scott I, Younes K, Yutsis M, Le Bastard N, Quinn J, van Dyck C, Nairn A, Fredericks C, Tian L, Kerchner G, Montine T, Sha S, Davidzon G, Henderson V, Longo F, Greicius M, Wagner A, Wyss-Coray T, Poston K, Mormino E, Andreasson K. Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer’s disease. Alzheimer's Research & Therapy 2022, 14: 172. PMID: 36371232, PMCID: PMC9652927, DOI: 10.1186/s13195-022-01116-2.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersCognitive DysfunctionHumansTau ProteinsConceptsPlasma p-tau181Alzheimer's Disease Research CenterP-tau181Disease Research CenterAlzheimer's diseasePositron emission tomographyAD dementiaBlood-based biomarker assaysAmyloid positron emission tomographyTreatment monitoringNovel blood-based biomarkersCSF p-tau181P-tau181 concentrationsDisease-modifying therapiesAβ42/Aβ40 ratioBlood-based biomarkersClinical AD diagnosisDetection of ADMild cognitive impairmentStudy cohortCSF biomarkersPlasma levelsAD groupPrognostic performanceCDR sum
2021
Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease.
Trelle AN, Carr VA, Wilson EN, Swarovski MS, Hunt MP, Toueg TN, Tran TT, Channappa D, Corso NK, Thieu MK, Jayakumar M, Nadiadwala A, Guo W, Tanner NJ, Bernstein JD, Litovsky CP, Guerin SA, Khazenzon AM, Harrison MB, Rutt BK, Deutsch GK, Chin FT, Davidzon GA, Hall JN, Sha SJ, Fredericks CA, Andreasson KI, Kerchner GA, Wagner AD, Mormino EC. Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease. Neurology 2021, 96: e1470-e1481. PMID: 33408146, PMCID: PMC8055319, DOI: 10.1212/wnl.0000000000011477.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAlzheimer DiseaseAmyloid beta-PeptidesAssociation LearningBiomarkersCross-Sectional StudiesCuesDiscrimination, PsychologicalFemaleHippocampusHumansMaleMemoryMemory DisordersMemory, EpisodicMental RecallMiddle AgedNeuropsychological TestsPeptide FragmentsPsychomotor PerformanceTau ProteinsConceptsMemory taskHippocampal functionMnemonic discrimination taskMnemonic discrimination performanceUnimpaired older adultsHippocampal-dependent memoryPreclinical Alzheimer's diseaseEpisodic memoryPreclinical AD pathologyIndividual differencesMemory assessmentMemory performanceDiscrimination taskTask difficultyAssociative memoryDiscrimination performanceSingle batch analysisCross-sectional relationshipMemory studiesOlder adultsMemoryAlzheimer's disease biomarkersCSF β-amyloidElevated p-tauRecall