Early affective changes and increased connectivity in preclinical Alzheimer's disease
Fredericks CA, Sturm VE, Brown JA, Hua AY, Bilgel M, Wong DF, Resnick SM, Seeley WW. Early affective changes and increased connectivity in preclinical Alzheimer's disease. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2018, 10: 471-479. PMID: 30302368, PMCID: PMC6174255, DOI: 10.1016/j.dadm.2018.06.002.Peer-Reviewed Original ResearchAffective changesEmotional reactivityPreclinical Alzheimer's diseaseInterpersonal warmthSocial-emotional processingEnhanced emotional reactivitySuperior temporal sulcusNormal older adultsSalience network connectivityHigher functional connectivityAmyloid-positive individualsHigh global connectivityMild Alzheimer's diseaseTemporal sulcusSalience networkSignificant stimuliRight insulaFunctional connectivityCognitive declineOlder adultsAffective symptomsAlzheimer's diseaseLongitudinal assessmentKey regionsWarmth