Caspase-3 in Postnatal Retinal Development and Degeneration
Zeiss CJ, Neal J, Johnson EA. Caspase-3 in Postnatal Retinal Development and Degeneration. Investigative Ophthalmology & Visual Science 2004, 45: 964-970. PMID: 14985318, DOI: 10.1167/iovs.03-0439.Peer-Reviewed Original ResearchConceptsTerminal dUTP transferase nick end labelingPostnatal retinal developmentCaspase-3Photoreceptor degenerationRod deathMutant miceRetinal developmentInner nuclear layerDouble mutant miceNick end labelingLight microscopic levelRod photoreceptor developmentCell nuclear antigenNeonatal deathRetinal morphometryDysplastic lesionsRetinal dysplasiaNuclear layerPhotoreceptor protectionImmunohistochemical stainingRodent modelsFactor VIICaspase-3 activationNuclear antigenEnd labelingProliferation of Microglia, but not Photoreceptors, in the Outer Nuclear Layer of the rd-1 Mouse
Zeiss CJ, Johnson EA. Proliferation of Microglia, but not Photoreceptors, in the Outer Nuclear Layer of the rd-1 Mouse. Investigative Ophthalmology & Visual Science 2004, 45: 971-976. PMID: 14985319, DOI: 10.1167/iovs.03-0301.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBiomarkersCDC2-CDC28 KinasesCell Cycle ProteinsCell DivisionCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 4Cyclin-Dependent KinasesDNA ReplicationImmunohistochemistryIn Situ Nick-End LabelingKi-67 AntigenMiceMice, Inbred C57BLMice, Mutant StrainsMicrogliaPhotoreceptor Cells, VertebrateProliferating Cell Nuclear AntigenProto-Oncogene ProteinsRetinal DegenerationConceptsOuter nuclear layerTerminal dUTP transferase nick end labelingNuclear layerCell cycle progressionMicroglial cellsPhotoreceptor deathCycle progressionProliferation of microgliaNick end labelingCell nuclear antigenControl miceNeurotrophic factorPeripheral gradientInner retinaNeuronal deathCell cycle proteinsPhotoreceptor lossRD-1Ki-67Postnatal dayPreexisting conditionsNeurodegenerative conditionsDouble immunolabelingBromodeoxyuridine uptakePhotoreceptor apoptosis