2014
Autonomous Metabolomics for Rapid Metabolite Identification in Global Profiling
Benton HP, Ivanisevic J, Mahieu NG, Kurczy ME, Johnson CH, Franco L, Rinehart D, Valentine E, Gowda H, Ubhi BK, Tautenhahn R, Gieschen A, Fields MW, Patti GJ, Siuzdak G. Autonomous Metabolomics for Rapid Metabolite Identification in Global Profiling. Analytical Chemistry 2014, 87: 884-891. PMID: 25496351, PMCID: PMC4303330, DOI: 10.1021/ac5025649.Peer-Reviewed Original ResearchConceptsMass spectrometry data acquisitionSystems biology levelMass spectrometry analysisBioinformatics resourcesGlobal profilingTandem mass spectrometry dataProfiling datasetsMass spectrometry databaseMass spectrometry dataSpectrometry analysisProfilingData acquisitionSpectrometry dataRapid metabolite identificationMetabolomic profilingUntargeted metabolomicsBacterial samplesMetabolomicsSimultaneous data processingIdentificationMetabolite identificationMetabolomics workflowsFliesAutomatic searchAutonomous approach
2013
Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database
Zhu ZJ, Schultz AW, Wang J, Johnson CH, Yannone SM, Patti GJ, Siuzdak G. Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database. Nature Protocols 2013, 8: 451-460. PMID: 23391889, PMCID: PMC3666335, DOI: 10.1038/nprot.2013.004.Peer-Reviewed Original ResearchMeSH KeywordsChromatography, LiquidComputational BiologyDatabases, FactualMass SpectrometryMetabolomicsSoftwareConceptsLiquid chromatography-quadrupole timeProfiling experimentsMETLIN metabolite databaseMore populationsSeven-step protocolFlight mass spectrometry characterizationMost biological samplesFlight mass spectrometryMass spectrometry characterizationTandem MSMetabolomic featuresQuadrupole timeComprehensive platformUntargeted metabolomicsMass spectrometryMS dataMETLIN databaseLC-Q-TOFMetabolitesMetabolite databasesBiological samplesThousands of peaks