2015
Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids
Kurczy ME, Zhu ZJ, Ivanisevic J, Schuyler AM, Lalwani K, Santidrian AF, David JM, Giddabasappa A, Roberts AJ, Olivos HJ, O’Brien P, Franco L, Fields MW, Paris LP, Friedlander M, Johnson CH, Epstein AA, Gendelman HE, Wood MR, Felding BH, Patti GJ, Spilker ME, Siuzdak G. Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids. Nature Communications 2015, 6: 5998. PMID: 25601659, PMCID: PMC4454288, DOI: 10.1038/ncomms6998.Peer-Reviewed Original ResearchConceptsF-AuNPsNon-polar moleculesTeflon-like coatingDesorption/ionizationFluorinated nanoparticlesGold nanoparticlesMass spectrometry imagingAnalyte desorptionRemarkable biocompatibilityMass spectrometry analysisElectron microscopyUnique propertiesMass spectrometryMultimodal imagingNanoparticlesContrast agentsSpectrometry imagingSpectrometry analysisFluorocarbonSynthetic bloodFluorocarbon liquidAuNPsLiquidNanostructuresBiocompatibility
2013
Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database
Zhu ZJ, Schultz AW, Wang J, Johnson CH, Yannone SM, Patti GJ, Siuzdak G. Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database. Nature Protocols 2013, 8: 451-460. PMID: 23391889, PMCID: PMC3666335, DOI: 10.1038/nprot.2013.004.Peer-Reviewed Original ResearchConceptsLiquid chromatography-quadrupole timeProfiling experimentsMETLIN metabolite databaseMore populationsSeven-step protocolFlight mass spectrometry characterizationMost biological samplesFlight mass spectrometryMass spectrometry characterizationTandem MSMetabolomic featuresQuadrupole timeComprehensive platformUntargeted metabolomicsMass spectrometryMS dataMETLIN databaseLC-Q-TOFMetabolitesMetabolite databasesBiological samplesThousands of peaks