Featured Publications
A connectome and analysis of the adult Drosophila central brain
Scheffer LK, Xu CS, Januszewski M, Lu Z, Takemura SY, Hayworth KJ, Huang GB, Shinomiya K, Maitlin-Shepard J, Berg S, Clements J, Hubbard PM, Katz WT, Umayam L, Zhao T, Ackerman D, Blakely T, Bogovic J, Dolafi T, Kainmueller D, Kawase T, Khairy KA, Leavitt L, Li PH, Lindsey L, Neubarth N, Olbris DJ, Otsuna H, Trautman ET, Ito M, Bates AS, Goldammer J, Wolff T, Svirskas R, Schlegel P, Neace E, Knecht CJ, Alvarado CX, Bailey DA, Ballinger S, Borycz JA, Canino BS, Cheatham N, Cook M, Dreher M, Duclos O, Eubanks B, Fairbanks K, Finley S, Forknall N, Francis A, Hopkins GP, Joyce EM, Kim S, Kirk NA, Kovalyak J, Lauchie S, Lohff A, Maldonado C, Manley EA, McLin S, Mooney C, Ndama M, Ogundeyi O, Okeoma N, Ordish C, Padilla N, Patrick CM, Paterson T, Phillips EE, Phillips EM, Rampally N, Ribeiro C, Robertson MK, Rymer JT, Ryan SM, Sammons M, Scott AK, Scott AL, Shinomiya A, Smith C, Smith K, Smith NL, Sobeski MA, Suleiman A, Swift J, Takemura S, Talebi I, Tarnogorska D, Tenshaw E, Tokhi T, Walsh JJ, Yang T, Horne JA, Li F, Parekh R, Rivlin PK, Jayaraman V, Costa M, Jefferis GS, Ito K, Saalfeld S, George R, Meinertzhagen I, Rubin GM, Hess HF, Jain V, Plaza SM. A connectome and analysis of the adult Drosophila central brain. ELife 2020, 9: e57443. PMID: 32880371, PMCID: PMC7546738, DOI: 10.7554/elife.57443.Peer-Reviewed Original ResearchConceptsCentral brainDrosophila central brainAdult Drosophila Central BrainGenetic reagentsFruit flyComputational compartmentsFly brainExhaustive atlasCell typesAnimal behaviorNeural motifsChemical synapsesDrosophilaSuch large data setsNeural circuitsFliesCompartmentalizationLarge fractionMotifSynapsesCell exampleCompartmentsNeuronsElectrical consequences
2023
Comparative connectomics and escape behavior in larvae of closely related Drosophila species
Zhu J, Boivin J, Pang S, Xu C, Lu Z, Saalfeld S, Hess H, Ohyama T. Comparative connectomics and escape behavior in larvae of closely related Drosophila species. Current Biology 2023, 33: 2491-2503.e4. PMID: 37285846, DOI: 10.1016/j.cub.2023.05.043.Peer-Reviewed Original ResearchConceptsRelated Drosophila speciesDrosophila speciesEscape behaviorDrosophilid speciesRelated speciesMelanogasterSantomeaVentral nerve cordPlausible mechanistic explanationCommon partnerBehavioral traitsMolecular componentsNoxious cuesComparative connectomicsUnderlying neural circuitsSpeciesDownstream partnersMDIVMechanistic explanation
2022
En bloc preparation of Drosophila brains enables high-throughput FIB-SEM connectomics
Lu Z, Xu C, Hayworth K, Pang S, Shinomiya K, Plaza S, Scheffer L, Rubin G, Hess H, Rivlin P, Meinertzhagen I. En bloc preparation of Drosophila brains enables high-throughput FIB-SEM connectomics. Frontiers In Neural Circuits 2022, 16: 917251. PMID: 36589862, PMCID: PMC9801301, DOI: 10.3389/fncir.2022.917251.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainConnectomeDrosophilaMicroscopy, Electron, ScanningSynapsesVolume Electron Microscopy
2019
Comparisons between the ON- and OFF-edge motion pathways in the Drosophila brain
Shinomiya K, Huang G, Lu Z, Parag T, Xu CS, Aniceto R, Ansari N, Cheatham N, Lauchie S, Neace E, Ogundeyi O, Ordish C, Peel D, Shinomiya A, Smith C, Takemura S, Talebi I, Rivlin PK, Nern A, Scheffer LK, Plaza SM, Meinertzhagen IA. Comparisons between the ON- and OFF-edge motion pathways in the Drosophila brain. ELife 2019, 8: e40025. PMID: 30624205, PMCID: PMC6338461, DOI: 10.7554/elife.40025.Peer-Reviewed Original Research
2018
A resource for the Drosophila antennal lobe provided by the connectome of glomerulus VA1v
Horne JA, Langille C, McLin S, Wiederman M, Lu Z, Xu CS, Plaza SM, Scheffer LK, Hess HF, Meinertzhagen IA. A resource for the Drosophila antennal lobe provided by the connectome of glomerulus VA1v. ELife 2018, 7: e37550. PMID: 30382940, PMCID: PMC6234030, DOI: 10.7554/elife.37550.Peer-Reviewed Original Research
2017
A connectome of a learning and memory center in the adult Drosophila brain
Takemura SY, Aso Y, Hige T, Wong A, Lu Z, Xu CS, Rivlin PK, Hess H, Zhao T, Parag T, Berg S, Huang G, Katz W, Olbris DJ, Plaza S, Umayam L, Aniceto R, Chang LA, Lauchie S, Ogundeyi O, Ordish C, Shinomiya A, Sigmund C, Takemura S, Tran J, Turner GC, Rubin GM, Scheffer LK. A connectome of a learning and memory center in the adult Drosophila brain. ELife 2017, 6: e26975. PMID: 28718765, PMCID: PMC5550281, DOI: 10.7554/elife.26975.Peer-Reviewed Original ResearchConceptsMB output neuronsDopaminergic neuronsKenyon cellsΑ-lobeMushroom bodiesAdult Drosophila brainUnderlying neuronal circuitsDirect synapseSlow depolarizationNeuronal circuitsSynaptic connectionsMemory centerDrosophila brainSynapsesNeuronsMemory formationOutput neuronsMajor siteSensory informationDAN activationSparse activitySensory modalitiesMemory recallUnanticipated classBrain
2015
Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics
Hayworth K, Xu C, Lu Z, Knott G, Fetter R, Tapia J, Lichtman J, Hess H. Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics. Nature Methods 2015, 12: 319-322. PMID: 25686390, PMCID: PMC4382383, DOI: 10.1038/nmeth.3292.Peer-Reviewed Original Research