A quantitative connection of experimental and simulated folding landscapes by vibrational spectroscopy
Davis CM, Zanetti-Polzi L, Gruebele M, Amadei A, Dyer RB, Daidone I. A quantitative connection of experimental and simulated folding landscapes by vibrational spectroscopy. Chemical Science 2018, 9: 9002-9011. PMID: 30647892, PMCID: PMC6301204, DOI: 10.1039/c8sc03786h.Peer-Reviewed Original ResearchMixed quantum/classical calculationsClassical calculationsExperimental observablesRelaxation dynamicsSame time scaleTemperature-jump experimentsProbe frequencyIntermediate stateReaction coordinatesVibrational spectroscopyExperimental observationsMolecular dynamics simulationsQuantitative connectionMolecular dynamics trajectoriesDirect structural evidenceObservablesTime dependenceSpectraTime scalesReaction kineticsHigh temperatureLow temperatureAmide IDynamics simulationsSpectral amplitude