2009
Alefacept for Severe Alopecia Areata: A Randomized, Double-blind, Placebo-Controlled Study
Strober B, Menon K, McMichael A, Hordinsky M, Krueger G, Panko J, Siu K, Lustgarten J, Ross E, Shapiro J. Alefacept for Severe Alopecia Areata: A Randomized, Double-blind, Placebo-Controlled Study. JAMA Dermatology 2009, 145: 1262-1266. PMID: 19917955, DOI: 10.1001/archdermatol.2009.264.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdolescentAdultAgedAlefaceptAlopecia AreataDermatologic AgentsDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleFemaleFollow-Up StudiesHumansInjections, IntramuscularMaleMiddle AgedNew York CityProbabilityRecombinant Fusion ProteinsRisk AssessmentSeverity of Illness IndexStatistics, NonparametricTreatment OutcomeYoung AdultConceptsSevere alopecia areataAlopecia areataPlacebo-controlled clinical trialEfficacy of alefaceptPlacebo-receiving groupSevere plaque psoriasisMain outcome measuresPlaque psoriasisPrevious therapyAlopecia ToolClinical trialsAlefaceptOutcome measuresUS FoodDrug AdministrationConsecutive weeksBiologic inhibitorsScalp hairAreataTreatmentWeeksSignificant improvementMulticenterPlaceboPsoriasis
2007
Alefacept for the treatment of psoriasis and other dermatologic diseases
Strober B, Menon K. Alefacept for the treatment of psoriasis and other dermatologic diseases. Dermatologic Therapy 2007, 20: 270-276. PMID: 17970892, DOI: 10.1111/j.1529-8019.2007.00140.x.Peer-Reviewed Original ResearchConceptsT cellsSeverity Index (PASI) 75 responseMemory effector T cellsNovel biologic agentsLong-term remissionEffector T cellsTreatment of psoriasisAntigen presenting cellsPathophysiology of psoriasisCourse of therapyDimeric fusion proteinPASI 75Plaque psoriasisAdverse eventsPsoriasis AreaBiologic agentsMore patientsLabel useImmunologic activationPresenting cellsIntramuscular injectionDosing strategiesAlefaceptDermatologic diseasesPsoriasis
2006
On multiple courses of alefacept
Leonardi C, Strober B. On multiple courses of alefacept. Journal Of The American Academy Of Dermatology 2006, 55: 916-917. PMID: 17052512, DOI: 10.1016/j.jaad.2006.04.075.Peer-Reviewed Original Research
2005
Successful Treatment of Plaque Psoriasis With Self-administered Subcutaneous Alefacept
Strober B. Successful Treatment of Plaque Psoriasis With Self-administered Subcutaneous Alefacept. JAMA Dermatology 2005, 141: 1602-1602. PMID: 16365271, DOI: 10.1001/archderm.141.12.1602-a.Peer-Reviewed Original ResearchAlefacept in the treatment of psoriatic nail disease: A small case series
Cassetty C, Alexis A, Shupack J, Strober B. Alefacept in the treatment of psoriatic nail disease: A small case series. Journal Of The American Academy Of Dermatology 2005, 52: 1101-1102. PMID: 15928640, DOI: 10.1016/j.jaad.2005.01.101.Peer-Reviewed Original Research