2023
Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial
Bikic A, Dalsgaard S, Pittman B, Leckman J, Wexler B. Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial. Nordic Journal Of Psychiatry 2023, 78: 87-91. PMID: 37905332, DOI: 10.1080/08039488.2023.2270954.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityChildCognitionCognitive TrainingHumansTreatment OutcomeConceptsAttention-deficit/hyperactivity disorderCognitive trainingDeficit/hyperactivity disorderComposite cognition scoreSessions of trainingCognitive functioningHyperactivity disorderCognitive improvementCognition scoresTraining sessionsMixed resultsFrequency of trainingTrainingChildrenSessionsIntervention groupCognitionInterventionFunctioningPost Hoc AnalysisScore outcomesControl groupPrevious studiesDisordersOutcomes
2022
Returning to basic principles to develop more effective treatments for central nervous system disorders
Wexler BE. Returning to basic principles to develop more effective treatments for central nervous system disorders. Experimental Biology And Medicine 2022, 247: 856-867. PMID: 35172621, PMCID: PMC9158240, DOI: 10.1177/15353702221078291.Peer-Reviewed Original ResearchMeSH KeywordsBrainCentral Nervous System DiseasesHumansMagnetic Resonance ImagingNeuronal PlasticityTreatment OutcomeConceptsCentral nervous systemPositron emission tomographyNeuroplastic processesMagnetic stimulationCentral nervous system disordersFunctional magnetic resonance imaging (fMRI) imagingNervous system disordersMagnetic resonance imaging (MRI) imagingSystem-based initiativesCNS diseasesClinical trialsEffective treatmentSystem disordersSide effectsNervous systemNew treatmentsClinical disordersCandidate drugsEmission tomographyBrain functionPreclinical research
2019
Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD
Smith SD, Crowley MJ, Ferrey A, Ramsey K, Wexler BE, Leckman JF, Sukhodolsky DG. Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD. Psychiatry Research 2019, 278: 248-257. PMID: 31233935, PMCID: PMC6637759, DOI: 10.1016/j.psychres.2019.06.021.Peer-Reviewed Original ResearchConceptsBehavioral measuresAttentional controlIntegrated brainGo/No-Go taskGo-P3 latencySlower reaction timesSocial interventionsRobust treatment effectAttentional systemADHD groupERP measuresDifference waveP3 latencyBrain activityADHDTAU groupEEG proceduresHealthy controlsHC groupReaction timeReplication purposesERPTreatment effectsChildrenSecondary goal
2016
Cognitive remediation for adults with schizophrenia: Does age matter?
Corbera S, Wexler BE, Poltorak A, Thime WR, Kurtz MM. Cognitive remediation for adults with schizophrenia: Does age matter? Psychiatry Research 2016, 247: 21-27. PMID: 27863314, PMCID: PMC5248553, DOI: 10.1016/j.psychres.2016.10.084.Peer-Reviewed Original ResearchConceptsCognitive remediationSubstantial individual differencesEarly chronic groupsOlder client populationNovel behavioral interventionSubsample of clientsRole of ageMemory measuresIndividual differencesStrategy acquisitionCognitive outcomesCognitive deficitsTask practiceRandomized control trialBehavioral interventionsTrend levelEmpirical supportSchizophreniaTreatment responseAge matterClient populationEarly-stage groupAge rangeGreater improvementAdultsExecutive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression
Morimoto SS, Gunning FM, Wexler BE, Hu W, Ilieva I, Liu J, Nitis J, Alexopoulos GS. Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression. American Journal Of Geriatric Psychiatry 2016, 24: 816-820. PMID: 27591163, PMCID: PMC5873289, DOI: 10.1016/j.jagp.2016.06.010.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionCognitive remediation interventionsComputerized cognitive remediationPoor treatment responseFavorable treatment responseTreatment responseCognitive remediationRemediation interventionsMajor depressionNeuropsychological performanceElderly patientsOlder adultsLate-life depressionMontgomery-Asberg Depression Rating Scale scoreTreatment-resistant major depressionDepression Rating Scale scoresRating Scale scoresDepressionAntidepressant treatmentTreatment trialsScale scorePatientsBaselineGreater reductionDysfunction
2015
Social skills training and computer-assisted cognitive remediation in schizophrenia
Kurtz MM, Mueser KT, Thime WR, Corbera S, Wexler BE. Social skills training and computer-assisted cognitive remediation in schizophrenia. Schizophrenia Research 2015, 162: 35-41. PMID: 25640526, PMCID: PMC5146951, DOI: 10.1016/j.schres.2015.01.020.Peer-Reviewed Original ResearchConceptsActive control conditionCognitive remediationComputer-assisted cognitive remediationComputer skills training programEvidence-based psychosocial interventionsCognitive remediation interventionsSocial skills trainingControl conditionSkills training programPerformance-based measuresRehabilitation interventionsStrategy trainingBody of researchNeurocognitive measuresRemediation interventionsSocial skillsSST programPsychosocial functioningPsychosocial interventionsSkills trainingImproved empathySkill groupsNeurocognitive functionPsychosocial functionTraining program
2014
Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression
Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS. Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression. Nature Communications 2014, 5: 4579. PMID: 25093396, PMCID: PMC4139707, DOI: 10.1038/ncomms5579.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionExecutive functionGeriatric depressionComputerized cognitive remediationTreatment-resistant geriatric depressionHistorical controlsBrain network abnormalitiesCognitive remediationPoor clinical outcomeGold standard treatmentRemission of symptomsOlder adultsClinical outcomesDepression treatmentMajor depressionDepressive symptomsNetwork abnormalitiesEscitalopramDepressionSymptomsGreater improvementTreatmentDeficitsRemissionParticipants
2012
Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study
Murthy NV, Mahncke H, Wexler BE, Maruff P, Inamdar A, Zucchetto M, Lund J, Shabbir S, Shergill S, Keshavan M, Kapur S, Laruelle M, Alexander R. Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study. Schizophrenia Research 2012, 139: 87-91. PMID: 22342330, DOI: 10.1016/j.schres.2012.01.042.Peer-Reviewed Original ResearchConceptsFunctional capacity outcome measuresCognitive Assessment InterviewBrain Fitness ProgramSignificant treatment effectOutcome measuresRegular antipsychotic medicationStable adult patientsNon-pharmacological methodsCognitive performanceTreatment effectsComputerized cognitive remediation trainingMultinational clinical trialsSingle-site studyTraining effectsCognitive remediation trainingOpen labelAdult patientsAntipsychotic medicationCAI scoreClinical trialsCognitive impairmentMulti-site studyExercise taskRemediation trainingNeuropsychological tasks
2008
Neurocognitive enhancement therapy with vocational services: Work outcomes at two-year follow-up
Bell MD, Zito W, Greig T, Wexler BE. Neurocognitive enhancement therapy with vocational services: Work outcomes at two-year follow-up. Schizophrenia Research 2008, 105: 18-29. PMID: 18715755, DOI: 10.1016/j.schres.2008.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognition DisordersCognitive Behavioral TherapyCombined Modality TherapyEmploymentEmployment, SupportedFemaleFollow-Up StudiesHumansMaleNeuropsychological TestsOccupational TherapyPsychiatric Status Rating ScalesPsychotherapy, GroupPsychotic DisordersRehabilitation, VocationalSchizophreniaSchizophrenic PsychologyTreatment OutcomeVocational EducationConceptsNeurocognitive enhancement therapyEnhancement therapyComputer-based cognitive trainingCommunity-based vocational servicesWeekly support groupsCognitive remediationCognitive trainingExecutive functionWork outcomesRemediation programVocational outcomesCommunity mental health centerMental health centersCognitive impairmentSixth quarterVocational servicesNet trainingTherapy outcomeSupport groupsCompetitive employmentSchizophreniaRehabilitation methodsSchizoaffective patientsEmployment programsTraining
2007
Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance
Bell M, Fiszdon J, Greig T, Wexler B, Bryson G. Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance. The Journal Of Rehabilitation Research And Development 2007, 44: 761. PMID: 17943687, DOI: 10.1682/jrrd.2007.02.0032.Peer-Reviewed Original ResearchConceptsNeurocognitive enhancement therapyWork therapyEnhancement therapyExecutive function tasksComputer-based trainingNonverbal memoryFunction tasksExecutive functionNeuropsychological performanceNeuropsychological testsNeuropsychological assessmentCognitive deficitsCompletion of trainingNeuropsychological improvementOccupational dysfunctionMemorySchizoaffective disorderCurrent studySchizophreniaTrainingJob placementWork activitiesActive interventionTaskAnalysis of variance
2005
Cognitive Remediation and Vocational Rehabilitation for Schizophrenia
Wexler BE, Bell MD. Cognitive Remediation and Vocational Rehabilitation for Schizophrenia. Schizophrenia Bulletin 2005, 31: 931-941. PMID: 16079390, DOI: 10.1093/schbul/sbi038.Peer-Reviewed Original ResearchMeSH KeywordsCognition DisordersCognitive Behavioral TherapyEmploymentHumansPrognosisSchizophreniaTreatment OutcomeVocational GuidanceConceptsCognitive remediation treatmentAspects of schizophreniaCognitive remediationCognitive deficitsWork functioningBehavioral interventionsWork therapyCognitionVocational rehabilitationArea of researchLasting improvementMental illnessSchizophreniaMajor mental illnessRemediation treatmentsFunctioningDeficitsInterventionMultiple studiesReadersResearchRehabilitationNeurocognitive enhancement therapy with work therapy: Productivity outcomes at 6- and 12-month follow-ups
Bell MD, Bryson GJ, Greig TC, Fiszdon JM, Wexler BE. Neurocognitive enhancement therapy with work therapy: Productivity outcomes at 6- and 12-month follow-ups. The Journal Of Rehabilitation Research And Development 2005, 42: 829. PMID: 16680620, DOI: 10.1682/jrrd.2005.03.0061.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyCombined Modality TherapyFollow-Up StudiesHumansMiddle AgedNeuropsychological TestsOdds RatioPatient ComplianceProbabilityPsychiatric Status Rating ScalesPsychotic DisordersRehabilitation, VocationalRisk AssessmentSchizophreniaTask Performance and AnalysisTime FactorsTreatment OutcomeConceptsNeurocognitive enhancement therapyWork therapyCognitive trainingEnhancement therapyComputerized cognitive trainingExecutive functionWork outcomesCommunity mental health centerDiagnosis of schizophreniaMental health centersMental hygiene clinicSchizoaffective disorderRandom effects analysisNet trainingProductivity outcomesTrainingRehabilitation programSchizophreniaMore hoursMemoryPresent studyDisordersOutcomesEffect analysisFindings
2003
Cognitive remediation of working memory deficits: durability of training effects in severely impaired and less severely impaired schizophrenia
Bell M, Bryson G, Wexler BE. Cognitive remediation of working memory deficits: durability of training effects in severely impaired and less severely impaired schizophrenia. Acta Psychiatrica Scandinavica 2003, 108: 101-109. PMID: 12823166, DOI: 10.1034/j.1600-0447.2003.00090.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyFemaleHumansMaleMemory DisordersMiddle AgedSchizophreniaSeverity of Illness IndexTreatment OutcomeConceptsNeurocognitive enhancement therapyWork therapyCognitive remediationTraining effectsSocial information processingCognitive training exercisesExecutive functionMemory performanceEnhancement therapyMemory deficitsInformation processingSeverity of impairmentDuration of trainingGreater improvementSchizoaffective disorderMemoryParticipantsTraining exercisesMost participantsImpairment severitySchizophreniaTrainingDuration of effectSeverity groupsDeficits
2001
Neurocognitive Enhancement Therapy With Work Therapy: Effects on Neuropsychological Test Performance
Bell M, Bryson G, Greig T, Corcoran C, Wexler BE. Neurocognitive Enhancement Therapy With Work Therapy: Effects on Neuropsychological Test Performance. JAMA Psychiatry 2001, 58: 763-768. PMID: 11483142, DOI: 10.1001/archpsyc.58.8.763.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCognitionCognition DisordersComputer-Assisted InstructionDichotic Listening TestsFeedbackFemaleFrontal LobeHumansMaleMemoryMultivariate AnalysisNeuropsychological TestsOccupational TherapyPsychomotor PerformancePsychotic DisordersSchizophreniaSchizophrenic PsychologyTeachingTreatment OutcomeConceptsNeurocognitive enhancement therapyEnhancement therapyWork therapyMental activityNeuropsychological testingLarge effect size improvementsExecutive function tasksNeuropsychological test performanceEffect size improvementsComputer-based trainingFunction tasksExecutive functionMemory performanceCognitive performanceNeuropsychological testsTraining tasksCognitive deficitsTest performanceComputer trainingCognitive dysfunctionIndependent outcome measureOccupational dysfunctionNatural contextSchizoaffective disorderMemory
1992
The Outpatient Treatment of Depression
WEXLER B, CICCHETTI D. The Outpatient Treatment of Depression. The Journal Of Nervous And Mental Disease 1992, 180: 277-286. PMID: 1533868, DOI: 10.1097/00005053-199205000-00001.Peer-Reviewed Original ResearchConceptsTreatment failure rateTreatment success rateTreatment dropout ratesInitial treatmentRoutine treatmentOutpatient treatmentEffective treatmentDepressed outpatientsSide effectsClinical practiceCombined treatmentRoutine useIndividual psychotherapyMultiple studiesSuccess rateTreatmentPharmacotherapyModest advantageFailure rateDropout ratePsychotherapyUnnecessary costsPatientsOutpatients